甲状旁腺激素样激素在胚胎发育中的作用 - 遗传.pdf

Hereditas (Beijing) 2014 年9 月, 36(9): 871 ―878 综 述 甲状旁腺激素样激素在胚胎发育中的作用 1,2 2 1 2 李园园 ，郭磊 ，卢晟盛 ，韩之明 1. 广西大学动物科学技术学院，南宁 530004 ； 2. 中国科学院动物研究所，计划生育生殖生物学国家重点实验室，北京 100101 摘要:甲状旁腺激素样激素(Parathyroid hormone-like hormone, PTHLH) 又称为甲状旁腺激素相关蛋白 (Parathyroid hormone-related protein, PTHrP) ，发现初期被认为是引起人类恶性肿瘤伴发的高钙血症的主要原因。 进一步的研究发现，PTHLH 在不同物种的多种成体和胎儿组织中均有表达，其生物学作用涉及形态发生、细 胞生长与分化的调控、胎盘钙的转运等多个方面。文章主要综述了PTHLH 的生物学特性及其在胚胎发育过程 中的作用，并进一步探讨了涉及的信号通路及可能的作用机制。 关键词:甲状旁腺激素样激素；胚胎发育；信号通路 Role of parathyroid hormone-like hormone during embryonic development 1,2 2 1 2 Yuanyuan Li , Lei Guo , Shengsheng Lu , Zhiming Han 1. College of Animal Science and Technology, Guangxi University, Nanning 530004, China; 2. State Key Laboratory of Reproductive Biology, Institute of Zoology , Chinese Academy of Sciences, Beijing 100101, China Abstract: Parathyroid hormone-like hormone (PTHLH), also known as parathyroid hormone-related protein (PTHrP), was first identified as a parathyroid hormone (PTH)-like factor responsible for humoral hypercalcaemia in malignancies. Subse- quent studies demonstrated that PTHLH has multiple physiological functions in many fetal and adult tissues, including the regulation of morphogenesis, cell proliferation and differentiation, and transplacental calcium transport. This review focuses on the biological characteristics of PTHLH and its function during embryonic development. The signaling pathway and poten- tial mechanism involved are further discussed. Keywords: parathyroid hormone-like hormone; embryonic development; signaling pathway 甲状旁腺激素样激素(Parathyroid hormone-like 因[1,2] [3]