浅谈Bonferroni事後校正.PDFVIP

鑷哄寳閱澶у 鐢熺墿绲辫▓鐮旂┒涓績 2015/02 娣鸿珖Bonferroni 浜嬪緦鏍℃ 鏋楀渐鍏 绲辫▓鍒嗘瀽甯 / 鍔╃悊鐮旂┒鍝 鏂肩当瑷堟瀹氭祦绋嬬暥涓紝鎴戝€戣棄鐢辨瘮杓僷 鍊艰垏鏌愮ó绋嬪害澶у皬鐨勬渶澶у蹇嶅瀷涓€瑾 宸鐜囦締姹哄畾瑙€瀵熷埌鐨勭祼鏋滄槸鍚﹀嚭鏂奸毃姗熶害鎴栫敱绯荤当鎬х殑鍥犵礌閫犳垚锛岄€欐ǎ鐨勫瀷涓€ 瑾ゅ樊鎴戝€戝畾缇╃偤伪0 锛岃€屾鍨嬩竴瑾ゅ樊姗熺巼涓€鑸湁鍏╃ó涓嶅悓鐨勫畾缇? 飦 Comparisonwise error rate (CER) 锛欳ER 浠ｈ〃鍊嬪垾妾㈠畾鎵€閫犳垚鐨勫瀷涓€瑾 宸€傜暥鎴戝€戣€冩叜CER 鏅傦紝瀵﹂殯鐨勫瀷涓€瑾ゅ樊姗熺巼閫氬父姣斘 渚嗙殑灏忋€ 0 飦 Familywise error rate (FWE) 锛欶WE 浠ｈ〃鎵€鏈夌殑绲辫▓妾㈠畾鎵€闆嗗悎閫犳垚鐨勫瀷 涓€瑾ゅ樊銆傜暥鎴戝€戣€冩叜FWE 鏅傦紝瀵﹂殯鐨勫瀷涓€瑾ゅ樊姗熺巼姣斘 渚嗙殑澶с€ 0 鍥犳锛屽煼琛屽柈涓€绲辫▓妾㈠畾鍙互淇濇寔CER 灏忔柤伪0 銆備絾鐣舵瀹氭暩鐩鍔犳檪锛孎WE 閫 甯告瘮闋愭湡鐨勪締鐨勫ぇ銆傝垑渚嬩締瑾紝5 绲勪箣闁撶殑骞冲潎鍊兼瘮杓冭嫢鎺＄敤鍠洜瀛愯畩鐣版暩鍒嗘瀽 (ANOVA) 锛孋ER 灏忔柤0.05 銆傝嫢鎺＄敤T 妾㈠畾妾㈠畾鍏╁叐绲勫垾涔嬮枔鐨勫樊鐣帮紝FWE 鍙兘 鏈€澶х偤 1 鈭 (1 鈭 伪)饊仒, where 饊仒 is the number of test = 1 鈭 (1 鈭 0.05)10 = 0.401 0.401 閬犲ぇ鏂肩爺绌跺垵鏈熸墍瑷畾鐨勬渶澶у蹇嶈宸?.05 锛屽洜姝ゆ垜鍊戦渶鎺＄敤鏌愮ó绋嬪害鐨勬牎 姝ｄ互閬垮厤閬庡害鎿村嫉鐨勫瀷涓€瑾ゅ樊姗熺巼 銆 鍦ㄨū澶氱敓閱牁鍩熺櫦琛ㄧ殑鏈熷垔锛屽湪鍠瘒鏂囩珷涓鍒板ぇ閲忕殑绲辫▓妾㈠畾p 鍊间甫涓嶅皯 瑕嬶紝姣斿瑾湪 锛 飦 瑾槑绲勫垾涔嬮枔鐨勫熀鏈爆鎬ч浼兼檪锛屾瀹氱祫鍒ヤ箣闁撶殑鍚勯爡浜哄彛瀛歌畩闋 锛屾湡 鏈涚祫鍒ヤ箣闁撴矑鏈夊樊鐣般€ 飦 鐣舵瘮杓冪祫鍒ュぇ鏂煎叐绲勬檪锛屾墍鏈夌殑鍏╁叐姣旇純閮芥瀹氥€ 飦 鐣舵湁澶氬€嬫脯閲忚畩闋呮檪锛屾渻浠ュ悇鍊嬩緷璁婇爡鑸囩浉鍚岀殑鑷畩闋呭缓绔嬫ā鍨嬩甫妾㈠畾 鍚勬ā鍨嬬暥涓殑鑷畩闋呴’钁楁€с€ 1 鑷哄寳閱澶у 鐢熺墿绲辫▓鐮旂┒涓績 2015/02 飦 鐣跺師鏈爯鏈熺殑鐩搁棞鎬т甫鏈櫦鐝 锛屼究閫茶鍒嗗堡鍒嗘瀽銆 飦 鍦ㄨ拷韫ゅ瀷鐮旂┒瑷▓涓紝鏈櫦鐝炬暣楂旇定鍕㈣畩鍖栵紝渚挎瀹氬悇鏅傞枔榛炲叐鍏╅枔鐨 宸暟銆傛垨鏄湪鍚勫€嬫檪闁撻粸妾㈠畾鍚勭祫鍒ヤ箣闁撶殑鍏╁叐宸暟 (Lang, 2004) 銆 涓婅堪鐨勪緥瀛愮殕鍙爆鏂间簨寰屾瀹 (post hoc test) 鐨勭瘎鐤囥€傜浉灏嶆柤浜嬪緦妾㈠畾锛屼簨 鍓嶆瀹 (priori test) 鎵€鏈夌殑姣旇純鍦ㄨ硣鏂欐湭鏀堕泦鍓嶇殕宸叉焙瀹氾紝涓嶆渻鍩疯澶氶鐒¤瑐鐨勬 瀹氾紝鍥犳浜嬪墠妾㈠畾澶氭暩鎺＄敤鍨嬩竴瑾ゅ樊姗熺巼鐐?.05 鑰屼笉闇€鏍℃銆傜劧鑰屽闅涗笂锛岃ū澶 鐨勭当瑷堟瀹氭槸鍦ㄨ硣鏂欏凡缍撹拹闆嗗畬鐣㈠緦鎵嶆焙瀹 锛屽嵆浣跨爺绌惰€呭彲鑳借獚鐐鸿嚜宸卞彧