A solid-phase extraction method for rapidly determining the adsorption coefficient of pharmaceuticals in sewage sludge（一种用于快速测定污水污泥中药物吸附系数的固相萃取方法）.pdfVIP

w a t e r r e s e a r c h 6 7 ( 2 0 1 4 ) 2 9 2 e2 9 8 Available online at ScienceDirect journal homepage: /locate/watres A solid-phase extraction method for rapidly determining the adsorption coefficient of pharmaceuticals in sewage sludge Laurence Berthod a,b, *,1, Gary Roberts a,2, David C. Whitley b, Alan Sharpe a,1, Graham A. Mills b a AstraZeneca Brixham Environmental Laboratory, Freshwater Quarry, Brixham, Devon TQ5 8BA, UK b School of Pharmacy and Biomedical Sciences, University of Portsmouth, Portsmouth, Hampshire PO1 2DT, UK a r t i c l e i n f o a b s t r a c t Article history: The partitioning of pharmaceuticals in the environment can be assessed by measuring their Received 25 April 2014 adsorption coefficients (K ) between aqueous and solid phases. Measuring this coefficient in d Received in revised form sewage sludge gives an indication of their partitioning behaviour in a wastewater treatment 2 September 2014 plant and hence contributes to an understanding of their subsequent fate. The regulatory Accepted 13 September 2014 approved method for measuring Kd in sewage sludge is the US Environmental Protection Available online 22 September 2014 Agencys Office of Prevention, Pesticides and Toxic Substances (OPPTS) guideline 835.1110, which is labour intensive and time consuming. We describe an alternative method for Keywords: measuring the Kd of pharmaceuticals in se