注射用硫酸奈替米星（Netimix sulfate injection for injection）.docVIP

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注射用硫酸奈替米星（Netimix sulfate injection for injection）.doc

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注射用硫酸奈替米星（Netimix sulfate injection for injection）

注射用硫酸奈替米星（Netimix sulfate injection for injection） Injection of Netilmicin Sulfate for Injection (SAN di new) The main ingredients of nanotubes sulfate for m star, its chemical name is: O oxygen - 4-3 - to - C - methyl - 3 - methyl amino - beta - L - Arab pyranose base (1-4) - O - (2, 6-2,3,4,6 amino - 2-4 to oxygen - alpha - D - glyceryl - 4 - ene f pyranose base - (1-6)] - 2 - deoxidation - N3 - ethyl - L - chain mildew amine sulfate. 【 properties 】 [pharmacological toxicology] Pharmacological effects The nanostar is a semi-synthetic aminoglucoside broad-spectrum antibiotic. The mechanism of action is the combination of the bacterial ribosomal 30S subunit, which can be used to inhibit the synthesis of normal proteins of sensitive microorganisms. This product has broad antibacterial effect, mainly for gram-negative bacillus genus and a handful of gram positive bacteria, including folic acid bacteria genera, enterobacter, escherichia coli, klebsiella bacillus coli, pseudomonas aeruginosa, Morgan deformation, salmonella species, shiga bacillus and staphylococcus aureus (resistance to penicillin, methicillin). In vitro, the product was also active in some isolated species of acinetobacter, neisseria, indol positive proteus, pseudomonas, and saratella. Most streptococcus and anaerobic organisms such as bacillus and clostridium are resistant to glucoside drugs. strychnos Genetic toxicity: the result of mutation was negative. Reproductive toxicity: the reproductive toxicity of rats showed that the product had no obvious effect on the fertility of animals, but pregnant women could injure the fetus. Carcinogenicity: lifetime cancer test results in rats and mice showed no drug-related tumors. [pharmacokinetics] According to PHYSICIANS DESK REFERENCE (54), the nanostar was quickly and completely absorbed after the injection. The serum concentration usually reaches 30 to 60 minutes after intramuscular injection. And the serum concentration (in MCG/ml) is usually about 3.0-3.5