C反应蛋白(CRP)（C-reactive protein (CRP)）.doc

C反应蛋白(CRP)（C-reactive protein (CRP)） The application of c-reactive protein (CRP) in pediatric clinic In 1930, Tillett and Francis first found a substance in the serum of patients with acute lobule pneumonia that had a specific precipitate response to c-polysaccharides in the cell wall of pneumococcus pneumoniae. In 1941, Avery was known to be a protein, so called c-reactive protein (CRP). In 1944, Jones used it as a secondary indicator of clinical rheumatic fever diagnosis. Later, CRP was detected in the acute phase serum of patients with non-infectious diseases and infectious diseases, and the CRP was thought to be a nonspecific response to tissue damage. Further studies have found that factors such as infection, infarction and immune complex deposition can lead to tissue injury. In the acute treatment of tissue damage, some plasma protein synthesized by the liver increased significantly, these proteins known as acute phase proteins, including CRP is acute phase proteins in one of the most significant changes. In recent years, with many sensitive, accurate and convenient detection means appeared, to review the research progress of CRP, faster, at present, the determination of its widely application in early diagnosis and differential diagnosis of clinical diseases. (1) biological characteristics: serum CRP (the following CRP without special indication) is synthesized by the liver. Interleukin 1b, 6 and tumor necrosis factor are the most important regulatory factors for the synthesis of the tumor [1, 2]. CRP of molecular weight of 105 500, the five - the same not glycosylation of polypeptide subunits, each subunit contains 187 amino acids, between the subunits by non covalent bond together five polymers, and have a chain between disulfide bond. The CRP is not heat-resistant, and can be destroyed at 66 degrees 30 minutes. If CRP is combined with choline and galactose residues, the classical pathway of complement can be activated and acted as the role of the modulator