老年人用药原则（The principle of drug use for the elderly）.docVIP

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老年人用药原则（The principle of drug use for the elderly）.doc

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老年人用药原则（The principle of drug use for the elderly）

老年人用药原则（The principle of drug use for the elderly） The third class The principle of drug use for the elderly Geriatric drug metabolism dynamics ?? Concept: abbreviated geriatric pharmacology, describes the elderly body to drug The function (absorption, distribution, metabolism and excretion) of the blood drug The time process and characteristics of the concentration fluctuation. In all processes of pharmacokinetics, there is a change in age, which can be directly The blood drug concentration that affects the elderly. Metabolic kinetic characteristics of aged drugs - absorption ?? Absorption -- a drug that penetrates the blood vessel from the site of the drug The process of entering the blood circulation. ?? Conclusion: the intestinal mucosa of the elderly is atrophied, the peristalsis slows down and the blood supply is decreased Low and gastric acid deficiency, but drug absorption (passive absorption of drugs) Less affected ?? Glucose, vitamin B1, calcium and iron: ?? For active transport absorption, age - up - absorption ?? Cause: the main carrier and enzyme activity of the drug are related Metabolic kinetic characteristics of aged drugs - absorption ?? Weak acid drugs: ?? The reason: ?? Stomach - acid of stomach acid, weak acid drug solution, stomach absorption rate, But the stomach is empty, the drug stays relatively high and the drug absorbs time ?? Small intestine - small intestinal peristalsis, drug absorption of the arrow to offset the small intestine blood supply The reduction of drug absorption due to decreased absorption of the unit Most of the drugs (drugs that are absorbed by the passive) are absorbed into the elderly and There was no significant difference between adults Metabolic kinetics of geriatric drugs - distribution ?? Distribution -- a drug that circulates through the blood The vascular walls are transferred to organs ?? 1. Effects of changes in body composition on drug distribution ?? Water-soluble drugs: ?? Atrophy of muscle and parenchyma, in