青霉素的重要论点（An important argument for penicillin）.docVIP

青霉素的重要论点（An important argument for penicillin） Patulin (patulin) is also called the great song, is a kind of poisonous fungi metabolites, can produce a fair penicillin penicillium fungi have expansion, penicillium, rod type mold penicillium, soil penicillium, New Zealand, penicillium, granular penicillium, mei Lin Qing mildew, arc penicillium, callie mold production, fructus penicillium, aspergillus, huge aspergillus, aspergillus and white silk table mould, etc. A total of 3 genera and 16 species of [1]. Penicillin mainly contaminated fruits and their products, especially apples, hawthorn, pears, tomatoes, apple juice and hawthorn. Toxicological tests showed that the penicillins had toxic effects on fertility, carcinogenesis and immunity, as well as a neurotoxin [2-3]. The limited standard of penicillin was 0 ~ 50Lg/kg in most European and American countries; The maximum limit standard for penicillin in apple juice is 0Lg/kg; Chinas corresponding standard [4-5] stipulates that apple and hawthorn products have a limited standard of 100Lg/kg, and the limited standard of juice, jam, fruit wine, canned and dried fruit is 50Lg/kg The physical and chemical properties of penicillin Chemical structural formula of patulin see chart, the formula for the C7 H6 m1, the molecular weight of 154, the chemical name for 4 - hydroxy - 4 - hydrogen furan (3, 2 - carbon) pian pyran - 2, 6 - hydrogen) ketone (4 - hy drox y - 4 h - furo (furo) l (3, 2 c) pyr the an - 2 (6 h) - one). Soluble in water, chloroform, acetone, ethanol and ethyl acetate, soluble in ether and benzene, insoluble in petroleum ether. Of the mustard family, having a colorless prismatic crystal melting point is 110. 5 ~ 112 e, such as chloroform, benzene, methylene chloride solvent can be more stable for a long period of time, gradually break down in the water and methanol, and instability in the alkaline solution, easily damaged, and increase stability in acid environment, solution to dry after the formation of the