晚期黄疸新生儿血液与母乳配对检测巨细胞病毒结果分析.pdfVIP

· 358· 中国妇幼保健2008年第23卷 晚期黄疸新生儿血液与母乳配对检测巨细胞病毒结果分析 胡洪波 魏中南 胡兴文 彭巧英 湖北省妇幼保健院 430070 中国图书分类号 11722．17 文献标识码 A 文章编号 1001-4411(2008)03-358-03 【摘 要】 目的：探讨晚期黄疸新生儿与母乳巨细胞病毒 (CMV)感染的相关性。方法：应用荧光定量PCR法配对检测 本院新生儿科2004年5月一2006年5月323例晚期黄疸患儿血和其母乳CMV—DNA含量，并检测血常规和肝功能，将结果进行 对比分析。结果：①新生儿血阳性者104例，阳性率为32．2％；母乳阳性者254例，阳性率为78．6％。②和吸食阴性母乳者相 比，吸食感染母乳的患儿更容易感染CMV(X2=15．88，P0．01)。③母乳CMV含量对患儿是否感染CMV没有显著性意义 (t=1．028，P0．05)。④早产儿较足月儿更容易感染CMV( =9．29，P0．叭)。结论：母乳CMV感染可能是导致新生儿晚 期黄疸的重要原因之一。 【关键词】 新生儿晚期黄疸 母乳 巨细胞病毒 A case control study on cytomegalovirus infection of late jaundice newborns blood and breast milk HU舶 一Bo，WEI Zhong—Nan，HU 一耽n，et a1．Maternal and Childrens Health Hospital of Hubei，Wuhan 430070．China 【Abstract] Objective：To investigate correlation between late neonatal jaundice and breast—milk—acquired cytomegalovirus infec- tions．Methods：323 eases of children with late jaundice were selected form May 2004 to May 2006 in our hospital，and detected CMV— DNA in these infants blood and their maternal breast milk by fluorescent quantitation PCR．Blood routine examination was perform ed and their liver function was examined and outcome data were analyzed contrastively．Results： ①Cytomegalovims—seropositive newborns were 104 cases，the positive rate was 32．2％；The positive rate of CMV—DNA of breast milk was 78．6％，cases were 254；~Compared to the breast milk noninfectious，newborns who via consumption of breast milk from cytomegalovirus—positive lactating mothers were more easily in— fected with CMV(X2=15．88，P0．01)；( The copies of CMV—DNA in breast milk could not determine whether newborns being infec· ted with CMV(t=1．028，P0．05)；④The premature infants were more easily infected with CMV than term infant(X2=9．29，P 0．01)．Conclusion：Breast—milk—acquired cytomegalovirus infections is a major cause of late neonatal jaundice in newborns． [Key words] Late neonatal jaundice；Breas