纳米抗体在癌症治疗中的应用.PDFVIP

生 物 工 程 学 报 吴越 等/纳米抗体在癌症治疗中的应用 1085 Chinese Journal of Biotechnology /cjbcn July 25, 2017, 33(7): 1085−1090 DOI: 10.13345/j.cjb.160491 ©2017 Chin J Biotech, All rights reserved ·综 述· 纳米抗体在癌症治疗中的应用 吴越，郝秀静，李敏 宁夏大学 西部特色生物资源保护与利用教育部重点实验室，宁夏 银川 750021 吴越, 郝秀静, 李敏. 纳米抗体在癌症治疗中的应用. 生物工程学报，2017, 33(7): 1085–1090. Wu Y, Hao XJ, Li M. Application of nanobody in cancer treatment. Chin J Biotech, 2017, 33(7): 1085–1090. 摘 要: 骆驼科动物的体内会产生一种缺失轻链的抗体，被称为重链抗体，又叫做 nanobody 。这种抗体只包 含一个可变区，具有高亲和力、高稳定性、强组织穿透性、高效表达等优点，同时具有低毒性和低免疫原性等 特性，适用于诊断、治疗和充当多种领域的实验研究工具。文中将主要讨论nanobody 在癌症治疗中的应用， 为nanobody 的进一步研发提供思路。 关键词: 重链抗体，纳米抗体，癌症治疗 Application of nanobody in cancer treatment Yue Wu, Xiujing Hao, and Min Li Key Laboratory for Conservation and Utilization of Special Biological Resources in the Western China, Ministry of Education , Ningxia University, Yinchuan 750021, Ningxia, China Abstract: Camelidae can produce a unique antibody that lacks light chain called variable heavy chain domain, also known as nanobodies. This antibody contains only one variable region, with high affinity, high stability, strong tissue penetration, efficient expression. Besides, their toxicity and immunogenicity are both low to be used for both therapeutic and diagnostic applications, as well as research tools. In this review, we discuss how nanobody has been explored as therapeutics in oncology, and provide ideas for the further development of nanobody. Keywords: heavy-chain-only antibodies, nanobodies, oncology [1]