过期妊娠胎盘滋养细胞Survivin表达情况的研究.pdfVIP

右江医学 2008年第36卷第3期 · 255 · 过期妊娠胎盘滋养细胞Survivin表达情况的研究 陈彩蓉 ，王自能 ，郭晓燕 ，刘坤平。，胡庆兰 (暨南大学医学院 1．附属第五医院清远市人民医院妇产科，广东清远 511 500；2．附属第一医院妇产科教研室， 广东广州 510630；3．附属第五医院清远市人民医院病理科，广东清远 511500) 【摘要】 目的 通过观察过期妊娠患者凋亡抑制蛋白Survivin在胎盘滋养细胞层的表达，探讨滋养细胞凋亡与过期妊娠的关 系。方法 采用免疫组织化学方法(S-P法)对10例过期妊娠和10例正常足月妊娠产妇的胎盘滋养细胞层Survivin表达进行检测 和对比研究。结果 结果胎盘滋养细胞层Survivin表达过期妊娠组为6．67±0．45，足月妊娠组为8．83±0．67，两组比较Survivin 表达差别有统计学意义(P dO．05)。结论 胎盘滋养细胞层凋亡抑制蛋白Survivin表达减少，可能与过期妊娠有关。 【关键词】 胎盘；过期妊娠；滋养细胞；凋亡；Survivin蛋白 文章编号：1003—1383(2008)02—0255—02 中图分类号：R 714．21 文献标识码：A Study on Expression of Survivin Protein in Trophoblast Cells of Placenta of Postdate Labor CHEN Cairong ，WANG Zineng ，GUOxiaoyan ，HUQinglan ，L 己，kunping。 (1．Department of Obestetrics and Gynecology of the Fifth Affiliated Hospital of Jinan University，Guangdong Qingyuan 5 1 1 500；2．Department of Obestetrics and Gynecology of the First Affiliated Hospital of Jinan University，Guangdong Guangzhou 510630；3．Department of pathobiology of the Fifth Affiliated Hospital of Jinan University，Guangdong Qingyuan 5 1 1 500) [Abstract] 0bjective To study the relationship between postdate labor and the trophoblast apoptosis by ob— serving the expression of Survivin protein in the trophoblasts of placenta．Methods Immunnohistochemistry was used tO detect the expression of Survivin protein in the trophoblasts of placenta which were taken from 10 samples of post— date 1abor and 10 samples of full-term 1abor．Results The expressionin of Survivin protein in the trophoblasts of post— date 1abor was(PU：6．674-0．45)and in full-term 1abor group was(PU：8．83士0．67)．The expression of Survivin protein in the trophoblasts of full—term labor was remarkably higher than that in the placenta of postdate labor．There was si