核素^99mTc—DTPA测定GFR与公式估算GFR的相关性研究.pdfVIP

．— — 200．—— 志2008年第21卷第3期J of Radioimmunolo~v2008．21 f3 核素9 Tc—DTPA测定GFR与公式估算GFR的相关性研究 上海交通大学医学院附属新华医院肾脏科(200092) 俞传琪 蒋更如’ 摘要 目的：探讨核素 Tc—DTPA测定GFR与MDRD公式、简化MDRD公式估算GFR的相关性。方 法：178例CKD患者，用核素 Tc—DTPA测定GFR，同时测定血清肌酐、尿素氮和白蛋白，根据年龄和性别分 别用MDRD和简化MDRD公式估算GFR。结果：核素 Tc—DTPA测定的GFR与MDRD公式估算的GFR有 显著性差异，P：0．0001，MDRD公式高估了GFR；核素 Tc—DTPA测定的GFR与简化MDRD公式估算的 GFR亦有显著性差异，P=0．0001，简化MDRD公式低估了GFR；MDRD公式估算的GFR与核素 Tc—DTPA 测定的GFR呈正相关，r=0．8292，P0．01；简化MDRD公式估算的GFR与核素 Tc—DTPA测定的GFR值 呈正相关，r=0．8277，P0．01。结论：MDRD公式、简化MDRD公式估算的GFR与核素 Tc—DTPA测得的 GFR有差异，需进一步校正后用于估算GFR。 关键词 慢性肾脏病 肾小球滤过率 核素 Tc—DTPA MDRD公式 简化MDRD公式 Comparison of the Glomerular Filtration Rate Estimated by Equation with That Assayed with Isotope mTc—DTPA Clearance Yu Chuanqi，Jiang Gengru Department ofNephrology，Xinhua Hospital Affiliated tO Shanghai Jiaotong University School ofMedicine，Shanghai(200092) Abstract Objective To investigate the cEffmences among the~lome~ar m~afion rates f CrR)estimated by MDRD equation (肋RD—Gnt)，estimatedby simplified肋RD equation(肋胁 一Gnt)and assayedwithisotope Tc一 clearance( Tc— GFR)．Methods Gnt Was assayed th isotope Tc—D1PA clearance in 178 patients with chronic kidney di8ease．GFRB were also calculated with both MDRD and modified MDRD equations．Serum creatlnine。u．rea nitrogen and alb-mln we．1e measured in all patients． Results There WeIe significant differences between Tc—Gnt and肋RD—Gnt，with肋RD ovexesthnation(P0．01)． re were also significant difference between Tc—GFR and modified肋胁 一GFR，with modified肋RD underestimation(P0．O1)． Boththe Gnb obtainedfromthetwo equationswe,re positively correlatedwiththeGnt obtainedwithisotope assay(P0．O1)．Conclu- sion There w唧 significant differences among the 99ⅢTc—Gnt，肋 RD—GFR and modified MDRD8一GFR．Adeql】卸c)r 0fthe presem two equations~e．iIl8