热熔挤出技术制备固体分散体的应用研究Application - 药学学报.PDF

药学学报 Acta Pharmaceutica Sinica 2012, 47 (2) : 163 167 ·163 · 热熔挤出技术制备固体分散体的应用研究 1 2 2 1 1* 陈美婉 , 文荣 , 陈桐楷 , 陈锐娥 , 王一涛 ( 1. 中药质量研究国家重点实验室 (澳门大学), 澳门大学中华医药研究院, 澳门 999078; 2. 广东药学院药科学院, 广东 广州 510006) 摘要: 热熔挤出技术主要用于提高难溶性药物的溶出度及其生物利用度, 具有工艺简单、连续化操作、生产 效率高和在线监测等优点, 已成为国外制备固体分散体的主导技术, 显示出独特的优势和应用潜力, 近年来受到 学工作者的广泛 注。本文综述了热熔挤出技术制备固体分散体的优势、工艺研究、载体材料和质量评价等 研究成果, 旨在为热熔挤出技术制备固体分散体的推广和应用提供参考和依据。 关键词: 热熔挤出技术; 固体分散体; 载体材料; 质量评价 中图分类号: R943 文献标识码:A 文章编号: 05 13-4870 (2012) 02-0163-05 Application research of hot-melt extrusion in preparation of solid dispersion 1 2 2 1 1* CHEN Mei-wan , CHEN Wen-rong , CHEN Tong-kai , CHEN Rui-e , WANG Yi-tao (1. The State key Laboratory of Quality Research in Chinese M edicine, Institute of Chinese Medical Sciences, University of Macau, Macau 999078, China; 2. College of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China) Abstract: Hot-melt extrusion (HME) is mainly used to enhance the dissolution rate and bioavailability of poorly water soluble drugs. It has many advantages, such as simple process, continuous operation, high efficiency, on-line monitoring and so on. HME provides an innovative approach, which has been concerned by pharmaceutical workers, for preparation of solid dispersion abroad. This article reviews recent advances on prepar