血液净化治疗毒鼠强急性中毒的临床研究.pdfVIP

蛇 志 Journal of SNAKE(ScienceNAture are KEy to health) 2008年第 2O卷第 2期 Vo1．20 No．2，2008 血液净化治疗毒鼠强急性中毒的临床研究 曹 杰 (广西医科大学一附院急诊科，广西南宁 530021) [摘要] 目的 观察血液净化治疗对毒鼠强急性中毒的疗效。 方法 在内科常规治疗的基础上，采用血液净化救治急性毒 鼠强中毒10例，并与单纯常规治疗的12例对照，比较两组的平均住院天数、治愈率以及APACHE m评分变化。 结果 血液 净化治疗组平均住院天数较常规治疗组明显缩短(P0．05)，治愈率明显提高(PO．05)；两组治疗后 APACHEⅢ评分均较治 疗前降低，其中血液净化组治疗后APACHEIrl评分降低尤为明显(PO．05)。 结论 血液净化是救治毒鼠强急性中毒的有 效方法。 [关键词] 血液净化；四亚甲基二砜四胺；中毒 [中图分类号] R959．4；R457；R459．5 [文献标识码] A [文章编号] 1001--5639(2008)02--0107--02 Clinical study of blood purification in treatment of acute tetramine poisoning CAO Jie (Department of emergency，the First Affiliated Hospital，Guangxi Medical University，Nanning，Guangxi，530021，China) Abstract： Objective To study the therapeutic effect of blood purification in acute tetramine intoxication patients． Methods 1 2 cases of acute tetramine poisoning received routine treatment were regarded as the control group，And 10 cases were given rou— tine treatment and blood purification as the observed group．Their average hospitalization time，curative rate and APACHEⅢ score were observed and compared． Results The curative rate of the control group was significantly higher than the control group(P~0．05)，The average hospitalization time of observed group was lower than the control group．And the patients A— PACHEⅢscore of the observed group decreased markedly after treament． Conclusion Blood purification therapy had good effect in acute tetramine intoxication patients． Key words： Blood purification；Tetramine；Poisoning 毒鼠强为剧毒的神经毒性杀鼠剂，中毒事件时有发生。 1．4 治疗方法 (1)内科常规治疗组。所有患者均予以下 其急性中毒主要表现为序贯发生的以颅脑损害症状相对突 治疗：①洗胃与导泄：人院后即予放置胃管，以温开水反复洗 出，同时伴有呼吸功能、心、肝及胃肠功能不全的多脏器功能 胃，其后经胃管注入活性碳 50 g吸附毒物，注入 2O 甘露醇 障碍综合征(MODS)，如不及时救治，将危及