BMPSmad信号通路与哺乳动物卵泡发生.PDFVIP

HEREDITAS (Beijing) 2009 3 , 31(3): 245―254 ISSN 0253-9772 综 述 DOI: 10.3724/SP.J.1005.2009.00245 BMP/Smad 信号通路与哺乳动物卵泡发生 王伟, 王少兵, 徐银学 , 210095 BMPs 属于TGF-β超家族成员, 在调节哺乳动物的生长、细胞增殖和分化等方面有很广泛的生物学功能。 越来越多的证据显示, BMPs 在雌性哺乳动物生殖, 尤其在卵泡发生过程中发挥重要作用。Smads 蛋白是BMP 家族细胞内信号转导分子, 可将BMPs 胞外信号从细胞膜传递入细胞核。文章对BMPs 、BMP/Smad 信号通路 和BMP 如何被调节进行概述, 并重点对BMP/Smad 信号通路在卵泡发生过程中所起的调控作用进行综述。 BMPs; Smads; 信号通路; 卵泡发生 Signal transduction of BMP/Smad and its relationship with mammalian folliculogenesis WANG Wei, WANG Shao-Bing, XU Yin-Xue College of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China Abstract: BMPs belong to the transforming growth factor-β superfamily. BMPs have been proved to have extensive bio- logical functions in mammals, including growth regulation, cell proliferation and differentiation. More and more evidence has shown that BMPs play a key role in fertility, especially in folliculogenesis in female mammals. Smad proteins are intra- cellular signaling transduction molecules of BMP family, which can transduce the BMP signal from the cell membrane to the nucleus. In this review, BMPs, BMP/Smad-related signal transduction and the regulation of BMP activity were summa- rized, and the regulatory roles of BMP/Smad signal transduction pathway in folliculogenesis were discussed. Keywords: BMPs; Smads; signal transduction; folliculogenesis (Bone morphogenetic proteins, BMPs) , 1 BMP β(Transforming growth factor-β, TGF-β) , 20 BMPs 1.1 BMP Smad BMP TGF-β 7 , BMP ( , ) , , BMPs BMP [1],