gold指南和lama的应用.pptVIP

* * Tiotropium significantly increased the time to first exacerbation (primary endpoint) compared with salmeterol by 42 days (187 vs 145 days in the first quartile of patients), corresponding to a 17% reduction in risk (HR 0.83; 95% CI 0.77-0.90; P0.001). Given that less than 50% of patients experienced an exacerbation, it was not possible to calculate the median time to first exacerbation, therefore the time to first exacerbation in the first quartile of patients was calculated instead. Randomized patients taking ≥1 dose of study medication included in analysis. COPD exacerbations with ons