小花异裂菊中的微量新成分英文.pdfVIP

·82 · 药学学报 Acta Pharmaceutica Sinica 2010, 45 (1): 82−86 Minor new constituents from Heteroplexis micocephala * FAN Xiao-na, LIN Sheng, ZHU Cheng-gen, YANG Yong-chun, SHI Jian-gong (Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education of PRC, Institute of Materia Medica, Chinese Academy of Medical Sciences Peking Union Medical College, Beijing 100050, China) Abstract : By using a combination of various chromatographic techniques including column chromatography over silica gel and Pharmadex LH-20 and reversed-phase HPLC, two minor new compounds, labda-12, 14-dien- 6β, 7α, 8β, 17-tetraol (1), 2, 3-cis-6-acetyl-5-hydroxy-2-(hydroxymethylvinyl)-2, 3-dihydrobenzofuran-3-ol angelate (2), and a minor new natural product 6-methoxy-4-methyl-3, 4-dihydro-2H-naphthalen-1-one (3) have been isolated from an ethanolic extract of Heteroplexis micocephala . Their structures were elucidated with spectroscopic data analysis including 2D NMR experiments. Key words: Heteroplexis micocephala ; minor constituent; diterpene; benzofuran derivative; 3, 4-dihydro- 2H-naphthalen-1-one derivative CLC number: R284.1 Document code: A Article ID : 0513-4870 (2010) 01-0082-05 小花异裂菊中的微量新成分 樊晓娜, 林 生, 朱承根, 杨永春, 石建功* ( 中国医学科学院、北京协和医学院药物研究所, 中草药物质基础与资源利用教育部重点实验室, 北京 100050) 摘要: 通过硅胶和 Pharmadex LH-20 凝胶柱色谱以及反相 HPLC 等多种分离技术的组合应用, 从小花异裂菊 全草乙醇提取物中分离得到了 2 个微量新化合物: