10.Neurofibrillary Tangle Formation as a Protective Response to Oxidative Stress in Alzheimer’s Disease医学电子书.pdfVIP

Oxidative Stress Hypothesis Neurofibrillary Tangle Formation as a Protective Response to Oxidative Stress in Alzheimer’s Disease Akihiko Nunomura, Atsushi Takeda, Paula I. Moreira, Rudy J. Castellani, Hyoung-gon Lee, Xiongwei Zhu, Mark A. Smith, and George Perry Abstract Neurofibrillary tangles (NFTs) composed of hyperphosphorylated tau are major hallmarks of Alzheimer’s disease (AD). Because the formation of NFTs reflects a hierarchy of neuron al vulnerability and their distribution parallels disease severity, NFTs formation has been suspected to play a major role i