中药六味安消联合左氧氟沙星根除幽门螺杆菌疗效观察.docVIP

中药六味安消联合左氧氟沙星根除幽门螺杆菌疗效观察【摘要】 目的 观察中药六味安消联合左氧氟沙星方案根除Hp的疗效。方法 选择Hp阳性慢性胃炎250例,随机分为A组128例和B组122例,A组口服埃索美拉唑20 mg加左氧氟沙星200 mg, 2次/d,1周,六味安消胶囊2.0 g, 3次/d,2周。B组口服埃索美拉唑片20 mg加阿莫西林分散片1 g加克拉霉素500 mg, 2次/d,1周。疗程结束1个月后行14C尿素呼气验检测Hp。结果 A组和B组HP根除率分别为84.2%和73.0%,差异有显著性(P0.05);A组和B组临床有效率分别为97.5%和94.8%,差异无显著性(P0.05)。结论 六味安消联合左氧氟沙星疗法比传统标准三联疗法的Hp根除率高,且与传统三联临床疗效相当,可作为根除Hp的治疗方案之一。 【关键词】 六味安消;左氧氟沙星;幽门螺杆菌 The clinical observation for eradication of Helicobacter pylori with traditional medicine liuweianxiao and levofloxacin REN Yi-ming, ZHU Cai-hong, CHEN Jian-hua, et al.The Fourth Clinic Hospital of YangZhou University,Department of Gastroenterology, NanTong Rich Hospital ,Nantong 226010, China 【Abstract】 Objective To investigate the efficacy of eradication of Helicobacter pylori(H pylori) with traditional medicine LiuWeiAnXiao and levofloxacin.Methods A total of 250 H pylori positive patients suffering from chronic gastritis were randomly allocated into two groups.Group A 128 patients received esomeprazole 20 mg + levofloxacin200 mg,twice daily for 1 wk, LiuWeiAnXiao 2 g, three times daily, for 2 wk.group B 122 patients received esomeprazole 20 mg + amoxicillin 1 g + clarithromycin 500 mg, twice daily for 1 wk.H pylori status was assessed 4 weeks after the end of treatment by 14C urea breath test.Results H prior eradication rates were 84.2% in group A and 73.0% in group B, respectively, and the difference was significant (P0.05).Conclusion The therapy withLiuWeiAnXiao and levofloxacin has a higher H prior eradication rates than traditional trigeminy therapy, and a same clinic effective to traditional trigeminy therapy.it is a feasible H pylori eradication regimen. 【Key words】 LiuWeiAnXiao; Levofloxacin; Helicobacter pylori(H pylori) 慢性胃炎、十二指肠溃疡和胃溃疡等疾病均与幽门螺杆菌(Helicobacter pylori,Hp)感染密切相关,根除Hp感染,是治疗上述疾病的关键措施之一[1]。作者应用传统中药六味安消联合左氧氟沙星根除Hp及治疗Hp阳性慢性胃炎患者,疗效可靠,兹报告如下。 1 资料与方法 1.1 病例选择标准 门诊慢性胃炎患者入选条件:①胃镜检查和病理活检诊断慢性非萎缩性胃炎;②快速尿素酶试验Hp阳性;③14C-呼气试验Hp阳性;④治疗前2周内未用过服抗菌药物、铋剂及抑酸剂;