抑郁症患者血清皮质醇水平研究.docVIP

抑郁症患者血清皮质醇水平研究【摘要】研究抑郁症患者血清皮质醇水平的影响因素。方法59例抑郁症患者和17例健康人在入组第1天早晨和下午测血清皮质醇水平，抑郁症患者入组当天评定HAMD。结果抑郁症组的皮质醇水平显著高于健康对照组，从健康对照组、轻中度抑郁组到严重抑郁组疗前下午血清皮质醇水平逐步升高，HAMD总分及各因子分与疗前早晨和下午血清皮质醇水平及其差值无显著相关，首次发作抑郁症患者皮质醇水平较反复发作者倾向为高，但无显著差异。结论部分抑郁症患者的皮质醇水平升高，抑郁症患者血清皮质醇水平与抑郁严重程度正相关。 【关键词】抑郁症；血清；皮质醇 Analysis the the serum concentration of cortisol in patients with depressionFU Qiang，ZHAO Peng ，YU Dong-shan. The Affiliated Brain Hospital of Nanjing Medical University，Nanjing,210029 【Abstract】ObjectiveTo invest the relationship between the serum concentration of cortisol and the severity of depression symptom in patients with depression. Materialsand method] 59 patients with depression were incorporated and 17 healthy as control group. The serum cortisol of each was surveyed in the afternoon at the first day in group as that in the morning. resultsThe serum concentration of cortisol in depression group were higher than the control.The serum concentration of cortisol in the patients with severe depression in the afternoon was higher than that in mild depression. The serum concentration of cortisol in the patients with mild depressionin the afternoon was higher than that in the control group. The total scores and factor scores were uncorrelated with the serum concentration of cortisol in despite of in the morning or afternoon. The serum concentration ofcortisol of the patients in the first depressive episode were higher than that of the patients in recurrent depression. But there were no significant difference between the two groups.conclusionThere arehighcortisol level in part of the patients with depression. The serum concentration of cortisol in the patients with depression was positively correlated with the severity of depressive symptom. 【Key words】Depression；Serum；Cortisol 在抑郁症的发病机制的各种假说中，生化机制的研究最被大家所重视，本文就其中皮质醇的作用进行了一定的探讨。 1对象和方法 １.１病例组：59例，2004年7月至2005年7月在南京脑科医院住院的患者。入组条件：（1）符合中国精神疾病分类与诊断标准第3版和国际疾病分类第10版的抑郁发作诊断标准；（2）汉密尔顿抑郁量表（HAMD）总分≥24分；（3）患者及患者家属同意检测皮质醇水平，并签订知情同意书；（4