早期使用呋塞米在足月新生儿重度窒息复苏后治疗中临床观察.docVIP

早期使用呋塞米在足月新生儿重度窒息复苏后治疗中临床观察【摘要】 目的 观察早期使用呋塞米在足月新生儿重度窒息复苏后治疗中的效果。方法 将我院2006年1月至2010年1月出生及治疗的98例重度窒息复苏后的足月新生儿，分为治疗组50例、对照组48例。治疗组在常规治疗基础上早期给予呋塞米治疗；对照组仅给予常规治疗，出现颅内高压症状时才给予降低颅内压治疗。结果 治疗组在治疗过程中临床表现为缺氧缺血性脑病（HIE）的发生率48.0%，头颅CT分度为中、重度缺氧缺血性脑病的发生率8.0%；而对照组则分别为68.8%和22.9%，两组比较差异有统计学意义（P＜0.05）。结论 早期使用呋塞米治疗重度窒息复苏后的足月新生儿，可预防和减少新生儿缺氧缺血性脑病的发生，值得临床进一步推广和应用。 【关键词】 新生儿；重度窒息；复苏；呋塞米 Therapeutic effect of Furosemide in the early time after serious asphyxia resuscitation in neonatesFENG Wen-qing.Maternal and Child Healthcare Hospital of Mei country，Guangdong 514700，China 【Abstract】 Objective To observe the therapeutic effect of furosemide in the early time after serious asphyxia resuscitation in neonates.Methods 98 neonates who had an entire information of serious asphyxia from January 2006 to January 2010 were divided into two groups，treatment group （50 cases）and control group （48 cases）.Furosemide was given in the early time on basis of conventional treatment in treatment group.Conventional treatment was applied in control group，reduced intracranial pressure when the symptoms of intracranial high pressure appear.Results The manifestation rate of hypoxic-ischemic encephalopathy（HIE）was 48.0%，the incidence of head CT graded middle and severe hypoxic-ischemic encephalopathy was 8.0%in treatment group，each was 68.8%，22.9% in control group. A statistically significant differencebetween the two groups（P＜0.05）. Conclusion Furosemide treatment in the early time after serious asphyxia resuscitation in neonates，can prevent and mitigate the hypoxic-ischemic encephalopathy，it is worthy of further promotion and application. 【Key words】 Neonate；Serious asphyxia；Resuscitation；Furosemide 作者单位：514700 广东省梅县妇幼保健院 新生儿重度窒息是新生儿期危急重症，良好的产、儿科合作是新生儿重度窒息复苏成功的关键，而复苏后的治疗更是重度窒息新生儿良好预后的关键。我院自2006年1月至2010年1月，采用早期给予呋塞米治疗重度窒息复苏后的足月新生儿50例，与48例早期仅采用常规治疗的患儿（仅在出现颅内高压症状时才给予甘露醇、呋塞米等降低颅内压治疗）进行对比研究，现将结果报告如下。 1 资料与方法 1.1 一般资料 98例重度窒息足月新生儿中，男54例、女44例，足月小样儿11例、正常体重儿72例、巨大儿15例；分娩方式：顺产10例、侧剪产20例、剖宫产68例；窒息相关因