灯盏花素注射液治疗老年糖尿病周围神经病变临床观察.docVIP

灯盏花素注射液治疗老年糖尿病周围神经病变临床观察[摘要] 目的:探讨灯盏花素注射液治疗老年糖尿病周围神经病变(DPN)的临床疗效。方法:回顾分析本院2007年2月～2009年2月收治的老年糖尿病周围神经病变患者48例,将其随机分为治疗组和对照组,各24例,治疗组在给予常规糖尿病治疗的同时给予灯盏花素治疗,观察其疗效。结果:治疗组总有效率为87.5%。其疗效结果、治愈及好转时间均有显著变化。血液流变学变化不明显,P0.05。结论:灯盏花素注射液治疗糖尿病周围神经病变效果比较肯定,值得进一步推广。 [关键词] 灯盏花素注射液;治疗;老年糖尿病周围神经病变 [中图分类号] R977.1 [文献标识码]B [文章编号]1674-4721(2010)06(a)-073-02 Clinical observation of breviscapine in the treatment of elderly diabetic peripheral neuropathy LU Xiuhong,HE Jing,YANG Yi (People’s Armed Police Corps Hospital,Guangdong Province,Guangzhou 510507, China) [Abstract] Objective: To explore the clinical efficacy of breviscapine in the treatment of elderly diabetic peripheral neuropathy (DPN). Methods: Slected 48 patients with diabetic peripheral neuropath in the hospital in February 2007 to February 2009,who were randomly divided into treatment group and control group,gave routine diabetes treatment,while the treatment group were given breviscapine to observe its efficacy. Results: The total effective rate of the treatment group was 87.5%. The results of their therapeutic,healing,and improved time had changed significantly. Hemorheology did not change significantly, P0.05. Conclusion: The efficacy of breviscapine in the treatment of diabetic peripheral neuropathy is well, and is worthy of further study. [Key words] Breviscapine;Treatment;Elderly diabetic peripheral neuropathy 糖尿病性周围神经病变患者应用灯盏花素注射液能明显改善临床症状,并且能明显改善患者正中神经和腓总神经传导速度,同时与营养神经的药物合用能明显提高疗效,对糖尿病性周围神经病变有防治作用[1-2]。本文笔者通过对2007年2月～2009年2月收治的老年糖尿病周围神经病变患者48例进行灯盏花素注射液治疗,效果显著,现归纳如下: 1 资料与方法 1.1一般资料 收集本院2007年2月～2009年2月收治的老年糖尿病周围神经病变患者48例(均符合1999年WHO诊断标准),其中,男27例,女21例;平均年龄(63.2±8.4)岁;糖尿病平均病程(15.3±7.4)年,糖尿病周围神经病变平均病程(3.7±1.2)年。将其随机分为两组,对照组24例,肌内注射维生素B1、维生素B12;治疗组24例,应用灯盏花素注射液治疗,两组1个疗程各3周。两组患者性别、年龄、病程等经统计学处理,差异无统计学意义(P0.05),具有可比性。 1.2 治疗方法 两组均进行常规糖尿病治疗,对照组均进行控制血糖,肌内注射维生素B1、维生素B12等一般常规治疗。治疗组在此基础上给予灯盏花素注射液(规格:10 mg/西林瓶),全部有药品不良反应(ADR)的患者为静脉滴注用药。每日1次给药。10 d为1个疗程,停药2 d后进行第2个疗程,共用2个疗程。治疗前后分别观察临床症状、血液流变学及肌电图变