血清总胆固醇水平及抑郁症患者自杀行为相关性研究.docVIP

血清总胆固醇水平及抑郁症患者自杀行为相关性研究【摘要】 目的探讨自杀未遂抑郁症患者的临床症状与其血清总胆固醇水平的关系。 方法抑郁症患者141人,分为伴自杀未遂组(56人)及无自杀行为组(85人),以汉密顿抑郁量表24项版本(HAMD?24)评定其临床症状,同时测定其血清总胆固醇水平(CHOL)。 结果自杀未遂组血清总胆固醇水平低于无自杀组[(4.32±1.02),(4.67±0.98), t =2.021, P =0.045];重度抑郁组血清总胆固醇水平低于中度组及轻度组[(4.26±0.94),(4.74±1.06),(4.86±1.14),F=3.393, P =0.037]。HAMD评分与血清总胆固醇水平呈负相关( r =?0.200, P =0.省略 The Relationship of Serum Cholesterol Concentration and Attempted Suicide of Patients with Depression WANG Xiang?lan,HONG Chun?xia,WEI Qin?ling,et al.Department of Psychiatry,The Third Affiliated Hospital of Sun Yat?sen University,Guangzhou,Guangdong,Guangzhou 510630,China 【Abstract】 ObjectiveTo explore relationship of serum total cholesterol concentration(CHOL)and attempted suicide in patients with depression. Methods141 patients with depression,85 patients were survivors from attempted suicide and 56 patients had never committed suicide.HAMD?24 was used to assess depressive severity and Hitachi Biochemistry Assay was used to determine CHOL in all patients. ResultsPatients with attempted suicide had lower CHOL than those without suicidal behavior[(4.32±1.02),(4.67±0.98), t =2.021, P =0.045].CHOL of severe depressive group was significantly lower than both moderate and mild depressive patients[(4.26±0.94),(4.74±1.06),(4.86±1.14),F=3.393, P =0.037].Total HAMD score was negatively correlated to CHOL( r =?0.200, P =0.035). ConclusionLow serum total cholesterol concentration may be a risk factor of suicidal behavior of depressive patients. 【Key words】 Depression; Suicide; Serum lipid 抑郁症(MDD)是常见的心身致残类疾病之一,25%以上患者有自杀未遂行为,而15%最终死于自杀,自杀未遂是再次发生自杀行为的重要危险因素[1],故对有自杀行为者生物学、心理社会因素等的研究倍受关注。近年来不少研究发现抑郁症患者的自杀行为可能和其血脂水平或血脂代谢有关,但尚无一致结论[2]。本研究拟通过和无自杀行为患者的对比,进一步分析抑郁症患者自杀行为和其血清胆固醇水平的相关性。? 1 资料与方法? 1.1 一般资料 2006年1月至2007年12月间中山三院精神科病区首次住院的抑郁症患者141人,均符合中国精神疾病分类与诊断标准第3版抑郁发作诊断标准,且年龄≥14岁,无高血压、糖尿病、高血脂症、甲状腺疾病等疾病。根据入院前2周内是否曾有自杀行为分为自杀未遂组和无自杀行为组两组。自杀未遂组56人,男19人,女37人;年龄:16岁~55岁,平均(32±11)岁;首次抑郁发作41人,反复抑郁发作15人;采取暴力方式(如割腕、跳楼、自缢等)自杀者32人;自杀未遂1次者50人