西酞普兰及米安色林治疗老年抑郁症对照探究.docVIP

西酞普兰及米安色林治疗老年抑郁症对照探究【摘要】 目的 比较西酞普兰与米安色林治疗老年抑郁症的疗效和不良反应。方法 将60 例老年抑郁症患者随机分为西酞普兰组和米安色林组。分别给予西酞普兰和米安色林治疗，疗程8周，采用汉密尔顿抑郁量表(HAMD)及不良反应量表(TESS)评定疗效和不良反应。结果 西酞普兰组和米安色林组显效率分别为83．3%和80．0%，二者疗效相当。HAMD评分西酞普兰组第2周末显著下降，而米安色林组治疗第1周末即显著下降，不良反应方面，西酞普兰组以口干、恶心、出汗增多、头昏、睡眠时间缩短为主，米安色林组则以嗜睡、口干、便秘为主。结论 西酞普兰和米安色林均为治疗老年抑郁症的安全有效的药物。 【关键词】 西酞普兰；米安色林；老年抑郁症 Comparative study of citalopram vs mianserin in treatment of elderly depressive patients WANG Yuan．chang，WANG Jing．li.The Health college of Zhumadian，Henan Province 463000，China 【Abstract】 Objective To compare the efficacy and safety of citalopram andmianserin in the treatment of elderly depressive patients.Methods 60 elderly patients with depression were randomly divided into citalopram group or mianserin group for 8 weeks respectively. The efficacy and side effects were evaluated by Hamilton depressive scale(HAMD)and treatment emergent symptom scale(TESS). Results The effective rates of citalopram andmianserin were 84．0%and 80．0%respectively，which was no significant difference between two groups.After eight weeks of treatment，the scores ofHAMD were significantly lower than before treatment in both groups.The scores ofHAMD decreased significantly at the end of the second week in citalopram group，but did at the end of the first week inmianserin group.The incidence of dry mouth、nausea、more sweat、dizzeness 、shorten sleepingin citalopram group than inmianserin group，while the incidence of somnolence、dry mouth 、constipation inmianserin group than in citalopram group.Conclusion Citalopramandmianserin are safe and effective drug in the treatment of geriatric depression. 【Key words】 Citalopram；Mianserin；Geriatric depression 西酞普兰是一种很强的具有选择性的5．羟色胺(5．HT)再摄取抑制剂，而米安色林是一种四环类抗抑郁药，二者在抑郁症的治疗中均具有高效安全的特点，但对老年抑郁症的治疗研究甚少，故本研究将两药用于老年抑郁症的 治疗，做对比研究，现将结果报告如下。 1 对象和方法 1．1 对象 为我院2004年1月至2006年8月门诊和住院患者，入组标准：①符合中国精神障碍分类与诊断标准第3版(CCMD．3)抑郁发作的标准；②首次发作；③年龄≥60岁；④汉密尔顿抑郁量表(HAMD)(前17项)评分≥18分；⑤排除严重躯体疾病，无酒精和药物依赖者；⑤血常规、肝功能检查均在正常范围者。共60例，随机分为2组。西酞普兰组30 例，男13