钳刮术前应用米非司酮加米索前列醇临床效果观察.docVIP

钳刮术前应用米非司酮加米索前列醇临床效果观察【摘要】 目的 探讨钳刮术前口服米非司酮加阴道放置米索前列醇终止11～15周妊娠的临床效果。方法 随机选择妊娠11～15周患者200例为观察组，行上述药物配合钳刮术；同期100例妊娠11～15周孕妇行宫旁神经阻滞麻醉人工流产钳刮术为对照组。观察两组宫颈扩张情况、术中出血量、手术时间、人流综合征情况及不全流产并发症。结果 观察组的宫颈扩张优于对照组，术中出血量明显少于对照组，手术时间短，较少发生人工流产综合征情况，两组比较差异有统计学意义（P＜0．05）。结论 钳刮术前口服米非司酮加阴道放置米索前列醇终止11～15周妊娠具有安全、有效及不良反应小的特点，值得临床推广。 【关键词】 米非司酮；米索前列醇；钳刮术 Clinical observation of applying mifepristone combined with misoprostol before curettageXU Yan．Department of Obstetrics and Gynecology，the Firste Hospital of Laohekou，Laohekou 441800， China 【Abstract】 Objective To evaluate clinical effect of mifepristone (taken orally) combined with misoprostol (laid in pudenda) before curettage for ending 11-15 weeks′ pregnancy．Methods 200 women (11-15 weeks′ pregnancy) randomly were divided into observation group ，received the above-mentioned drugs and curettage; correspondingly 100 women(11-15 weeks′ pregnancy) as control group ，received artificial abortion under uterine nerve block anaesthesia．the following between the 2 groups such as dislatation of cervix，bleeding during operation，operative time，the syndrorne of artificial abortion and incomplete abortion complication were observed．Results There were marked differences (P＜0．05),the observation group obtained better effect than control group， the dilatation of cervix was better，the bleeding was less，the operative time was less，the syndrome of artifical obortion was less happening．Conclusion Mifepristone combined with misoprostols before curettage is safe and efficient treatment with mild side-effects for ending 11-15 weeks′ pregnancy,it′s worth clinically to spreading． 【Key words】 Mifepristone；Misoprostol；Curettage 终止11～15周妊娠需行钳刮术，因胎儿较大，直接手术操作难度大、风险高、并发症多。我院自2005年3月以来应用钳刮术前口服米非司酮加阴道放置米索前列醇终止11～15周妊娠，取得较好效果，现报告如下。 1 资料与方法 1．1 研究对象 2005年3月至2006年9月来院行钳刮术的自愿受术孕妇300例，孕周11～15周，经妇科检查及B超检查证实为宫内妊娠，且胎儿大小与孕周相符（胎儿头臀长＜7 cm），各项常规检查正常。年龄17～42岁，初孕120例，经孕未产100例，经产80例，随机分为研究组（200例）和对照组（100例），两组年龄、孕产次及孕龄分布差异无统计学意义（P＞0．05）。所有研究对象均无药物过敏史、前列腺素应用禁忌证、凝血系统功能