非甾体类消炎药不良反应相关探究.docVIP

非甾体类消炎药不良反应相关探究【摘要】 目的 分析比较几种常用的非甾体类消炎药(布洛芬、双氯芬酸、美洛昔康)的不良反应。 方法 将160例骨关节炎、类风湿性关节炎患者随机分成3组,分别予以布洛芬、双氯芬酸、美洛昔康治疗6个月,观察比较其消化道、心血管系统不良反应及血象变化。 结果 布洛芬组患者消化道损害发生率显著高于美洛昔康组,有统计学意义;三组患者心血管事件的发生率无统计学差异,血象变化亦无统计学差异。 结论 选择性COX-2抑制剂的消化道损害显著低于非选择性的非甾体类消炎药,但其对于心血管事件的不良影响尚不明确,临床医师用药需谨慎。 【关键词】 非甾体类消炎药;消化道损害;心血管事件 Research on side effects of non-steroidal anti-inflammatory drugs(nsaids) CHEN Xi.Department of Pharmacy, Chinese Medicine Hospital, Zhabei District, Shanghai 200072,China 【Abstract】 Objective To analyze and compare the side effects of several commonly used NSAIDs.Methods 160 patients suffering from osteoarthritis and rheumatoid arthritis were randomly divided into three groups, and were treated with Ibuprofen, Diclofenac and Meloxicam respectively for 6 months.Then we observes their side effects on digestive and cardiovascular systems, and the changes of blood cells as well.Results The rate of digestive damage was much higher in Ibuprofen group than in Melocixam group with statistical significance.There was no significant difference as for the rate of cardiovascular accidents among these three groups.It was the same case with blood cells.Conclusions Selective COX-2 inhibitors have obviously less digestive damage than non-selective NSAIDs.However, their side effects on cardiovascular system are still not clear, so clinical physicians should be more careful when using these drugs. 【Key words】 Non-steroidal anti-inflammatory drugs(NSAIDs);Digestive damage; Cardiovascular accidents 非甾体类消炎药(non-steroidal anti-inflammatory drugs,NSAIDs)是一类通过抑制环氧化酶(cyclooxygenase,COX)减少前列腺素(PGs)合成而起到解热、镇痛、抗炎、抗风湿和抗血小板聚集作用的药物。临床上广泛用于骨关节炎、类风湿性关节炎、多种免疫功能紊乱性疾病、炎症性肠病以及缓解各种疼痛症状。然而,NSAIDs在为广大患者减轻病痛的同时,也带来了许多不良反应,如消化性溃疡及其并发症、心血管事件、肾功能损害、骨髓抑制等,使该类药物的应用受到了一定程度的限制。本文就本院常用的几种非甾体类消炎药(布洛芬缓释胶囊、双氯芬酸钠缓释片、美洛昔康片)的不良反应做一分析比较,为临床医师用药提供一定的参考。 1 资料与方法 1.1 研究对象 2008年1月至2008年12月于上海市闸北区中医医院就诊的160例骨关节炎、风湿性关节炎或类风湿性关节炎患者,其中男72例,女88例,平均年龄(56.6±8.2)岁。160例患者之前1个月内均未服用任何非甾体类消炎药,无消化性溃疡、消化道出血、急性冠脉综合征、急性心肌梗死等