自噬在肝稳态调节作用中的研究进展.pdf

生 物 工 程 学 报 黄慧 等/ 自噬在肝稳态调节作用中的研究进展 1185 Chinese Journal of Biotechnology /cjbcn September 25, 2016, 32(9): 1185−1193 DOI: 10.13345/j.cjb.150561 ©2016 Chin J Biotech, All rights reserved 综 述 1,2 1,2 1,2 黄慧 ，李洪艳 ，邹伟 1 116081 2 116081 , , . . , 2016, 32(9): 1185–1193. Huang H, Li HY, Zou W. Progress of autophagy in regulating liver homeostasis. Chin J Biotech, 2016, 32(9): 1185–1193. 摘 要: 肝脏是人体最大的消化腺，也是最主要的代谢器官。自 20 世纪 60 年代，人们在肝脏溶酶体的研究 中提出“ 自噬”这一概念时，就发现肝脏内的营养水平与激素影响自噬活动。近年来的研究表明，自噬不仅是正 常的生理过程，也参与许多病理过程的调节。本文介绍了自噬在健康肝脏中维持稳态的作用，旨在为肝脏生理 学及自噬失调相关疾病的治疗提供新思路。 : 肝脏，稳态，自噬，代谢，调节 Progress of autophagy in regulating liver homeostasis Hui Huang1,2, Hongyan Li1,2, and Wei Zou1,2 1 College of Life Science, Liaoning Normal University , Dalian 116081, Liaoning , China 2 Liaoning Key Laboratories of Biotechnology and Molecular Drug Research and Development, Dalian 116081, Liaoning , China Abstract: Liver is the largest human digestive gland and the most important metabolic organ. When autophagy was proposed during studying liver lysosomes in the 1960s, it was found that nutrient levels and hormones could influence autophagy activity. Recent studies show that autophagy is not only normal physiological processes, but also involved in the regulation of many pathological processes. This article summarizes the role of liver autophagy in the maintenance of homeostasis in the healthy liver, and provides new ideas for liver physiology and treating diseases associated with autophagy disorders. Keywords: liv