什么是夫妻什么是家（What is a husband and wife What is home）.doc

什么是夫妻什么是家（What is a husband and wife What is home） The research progress of liposomes lung Biru, shao wei * (school of pharmacy, shandong university, jinan 250012) Abstract: the paper introduces the characteristics and methods of the liposome pulmonary drug delivery, in recent years were reviewed at home and abroad about liposome as a drug antibiotic, antiasthmatic, anti-cancer drugs, polypeptide and protein drugs and gene drug carrier, by local or systemic effectiveness of pulmonary medicine research, and evaluate its safety. Keywords: liposomes; The lungs give the medicine; Drug carrier; security The liposomes have a long history of lung administration and have been used to treat respiratory distress syndrome. McCullough, etc in 1979 [1] found beta cytarabine solution after tracheal drip quickly cleared from lung, and its liposome suspension liquid is hardly redistribution to other organizations, and has kept in bronchial space, so the early research focused on the lung local treatment of the disease. As genetic drugs, pharmaceutical excipients, the development of new devices and new drug delivery technology, as well as liposomes itself has high bioavailability, less adverse reaction, sustainable slow drug release properties, liposomes as a carrier of the local or systemic drugs for pulmonary drug delivery is increasingly valued, is presently as follows the summary of relevant research progress. 1. The characteristics of liposomal lung Compared with other methods of drug administration, the lung has the following characteristics: it is convenient for the medicine, and it is mainly inhaled by inhalation, and the patient is highly compliant. The absorption surface area is large, the absorption area is rich in blood flow, the medicine classics air - blood way exchange distance is short, the speed is quick. The lungs are composed of single-layer epithelial cells, with a thin epithelial barrier and high membrane permeability, which can effectively deliver macromolecula