抗抑郁治疗对伴抑郁症状慢性阻塞性肺疾病患者生存质量影响.doc

抗抑郁治疗对伴抑郁症状慢性阻塞性肺疾病患者生存质量影响[摘要] 目的 观察抗抑郁治疗对合并抑郁症状的慢性阻塞性肺疾病（chronic obstructive pulmonary disease，COPD）生存质量的影响。 方法 将伴抑郁症状的92例COPD患者随机分为两组，抗抑郁治疗组在常规针对COPD治疗基础上给予心理干预和氟西汀口服6个月，对照组仅给予常规针对COPD治疗。分析两组治疗前后生存质量评分、6个月内两组再住院率及生存率。 结果 COPD患者中合并抑郁障碍发生率为42.59%；治疗6个月后，抗抑郁治疗组生存质量评分主要指标日常生活能力、社会活动能力、抑郁症状、焦虑症状方面均明显改善（P 0.05）。 结论 心理干预和药物抗郁抑治疗可提高伴郁抑症状的COPD患者生存质量，降低再入院率。 [关键词] 慢性阻塞性肺疾病；抑郁；生存质量 [中图分类号] R563.9 [文献标识码] A [文章编号] 1673-7210（2012）07（a）-0060-03 Effects of anti-depression therapy on the life quality of chronic obstructive pulmonary disease patients combined with depression MA Rongwu LUO Siping The People’s Hospital of Tiandong County, Guangxi Zhuang Autonomous Region, Tiandong 531506, China [Abstract] Objective To observe the effects of anti-depression therapy on the life quality of chronic obstructive pulmonary disease (COPD) patients combined with depression. Methods 92 cases of COPD patients combined with depression were randomly divided into two groups. Anti-depression therapy group was treated with mental intervention and oral administration of Fluoxetine for 6 months, on the basis of routine COPD therapy. The control group was given routine COPD therapy. The life quality scores before and after therapy, re-hospitalization rates in 6 months and survival rates of the two groups were analyzed. Results The incidence of depression among COPD patients was 42.59%. After 6-months therapy, the primary indexes of life quality score, including daily living activities, social activities, depression and anxiety of the anti-depression therapy group were significantly improved (P 0.05). Conclusion Mental intervention and drug anti-depression therapy can improve the life quality and decrease the re-hospitalization rate of COPD patients combined with depression. [Key words] Chronic obstructive pulmonary disease; Depression; Life quality 慢性阻塞性肺疾病（chronic obstructive pulmonary disease，COPD）是以不完全可逆的气流受限为特征的一组慢性气道炎症性疾病，由于疾病长期迁延不愈，躯体及心理的双重压力使患者容易出现精神障碍，发展成为生理和心理共同存的在的疾病状况。然而，