星状神经节阻滞联合舍曲林治疗原发性早泄.doc

星状神经节阻滞联合舍曲林治疗原发性早泄【摘 要】 目的:观察舍曲林联合星状神经节阻滞(SGB)治疗原发性早泄(PE)的近期疗效和安全性。方法:原发性PE患者50例，随机分为两组，每组25例。药物组每日口服舍曲林50mg；联合组（舍曲林+SGB组）每日口服舍曲林50mg，同时每周两次SGB，两组疗程共4w。评价治疗前后阴道内射精潜伏期(IELT)的变化；同时以问卷形式评价治疗前后射精控制感、性满意度、焦虑程度、人际关系紧张程度的变化；并进行组间对比。结果:与治疗前相比，治疗后两组IELT均有明显延长,药物组和联合组分别从治疗前的(0.75±0.36)分和(0.77±0.29)分，增加到治疗后的(2.63±1.66)分和(2.71±1.57)分；治疗前后IELT的差异有显著性，而组间IELT差异无显著性。两组治疗后射精控制感、性满意度、焦虑程度、人际关系紧张程度都有明显改善。联合组的射精控制感和性满意度优于药物组，差异具有显著性。结论:SGB与舍曲林联合治疗，可以有效地延长IELT，其效果与单纯舍曲林治疗无差异。但是，联合治疗可以更好地提高患者对射精的控制能力和性满意度。因此，SGB能否作为一种有效治疗原发性PE的手段，还有待于进一步临床验证。 【关键词】 原发性早泄; 星状神经节阻滞；阴道内射精潜伏期 Sertraline combined with stellate ganglion block in treatment of premature ejaculation ZHANG Guoxi?1， WANG Xiaofeng?1, BAI Wenjun?1， YANG Junjun?2 1 Department of Urology，PeoplesHospital, Peking University, Peking 100044, China 2 Department of Anesthesiology，People’sHospital, Peking University, Peking 100044, China 【Abstract】 Objectives: To investigate on the efficacy and safety of sertraline combined with stellate ganglion block（SGB）in treatment of premature ejaculation（PE).Methods： A total of 50 patients with PE were randomly enrolled into 2 groups，each including 25 members. Over a 4-week treatment period, the sertraline group took sertraline 50mg once a day；and the combined group（Sertraline with SGB）were given both sertraline 50mg once a day as well as SGB therapy twice a week. All patients finished PE questionnaires which include 4 items （perceived control over ejaculation, personal distress related to ejaculation, satisfaction with sexual intercourse, interpersonal difficulty related to ejaculation）, and estimated intravaginal ejaculation latency time(IELT) was recorded. Results：After treatment, IELT increased for both group, from baseline（4.34±2.12）to（3.65±2.23）min in sertraline group, and from（6.23±2.66）, to（5.22±3.22）in combined group, respectively. Moreover, the improvements of IELT and PRO achieved were more satisfied in combined group than in sertraline group. The differences were signific