妇科恶性肿瘤的精准治疗研究进展 - 肿瘤药学.PDFVIP

肿瘤药学 2017 年 2 月第 7 卷第 1 期　Anti-tumor Pharmacy, February 2017, Vol. 7, No. 1 - 1 - ●综　　述● 妇科恶性肿瘤的精准治疗研究进展 １ 2 2 1 1 2* 洪　婷 ，罗晨辉 ，王　瑛 ，陈　嫣 ，许一诺 ，王 静 1 2 （南华大学，湖南 衡 阳， 1000 1； 湖南省肿瘤 医院/ 中南大学湘雅 医学院附属肿瘤 医院，湖南 长沙， 100 13 ） 摘要：精准治疗是通过二代测序等方法获取最先进的基因特征谱，结合临床和病理资料，设计针对每个患者的个性化诊 断、预后、治疗方案。本文综述了妇科恶性肿瘤（卵巢癌、宫颈癌、子宫内膜癌）不同靶点（BRCA1/2、HER2 基因、血管内皮生 长因子）的分子靶向治疗及免疫治疗的相关研究进展。 关键词：妇科恶性肿瘤；靶向治疗；免疫治疗；精准治疗 中图分类号：R737.3　文献标识码 ：A　文章编号：2095-1264（2017）01-0001-06 doi：10.3969/j.issn.2095-1264.2017.01.01 Research Progress of the Precision Therapy for Gynecological Oncology 1 2 2 1 1 2* HONG Ting , L UO Chenhui , WANG Ying , CHEN Yan , X U Yinuo , WANG Jing 1 2 ( University of South China, Hengyang, Hunan, 421001, China; Hunan Cancer Hosp ital / the Aff iliated Cancer Hosp ital of Xi- angya School of Medicine, Central South University, Changsha, Hunan, 410013, China) Abstract: The precision medicine is to obtain the most advanced Genome Atlas through the next generation sequencing, and combining the clinical and pathological data, to design personalized diagnosis, prognosis and treatment for individual patient. In this paper, we mainly reviewed the research development of molecular therapies on different targets (BRCA1/2, HER2gene, vascular endothelial growth factor) of gynecologic malignant tumors (ovarian cancer, cervical cancer, endometrial cancer), as well as the related immune therapies. Key words: Gynecological oncology; Targeted therapy; Immune therapy; Precision therapy