脉君安片主要降压成分葛根素和氢氯噻嗪在大鼠体内的药动学研究.PDF

1056 药学学报 Acta Pharmaceutica Sinica 2009, 44 (9) : 1056 1060 ·研究简报· 脉君安片主要降压成分葛根素和氢氯噻嗪在大鼠体内的药动学研究 仙, 韩凤梅, 杜 鹏, 陈 勇* (湖北大学中药生物技术省重点实验室, 湖北 武汉 430062) 关键词: 葛根素; 氢氯噻嗪; 脉君安片; 药动学 中图分类号: R917 文献标识码:A 文章编号: 05 13-4870 (2009) 09-1056-05 Pharmacokinetics of puerarin and hydrochlorothiazide from Maijunan tablets in rats * ZHANG Xian, HAN Feng-mei, DU Peng, CHEN Yong (Hubei Province Key Laboratory of Biotechnology of Traditional Chinese Medicine, Hubei University, Wuhan 430062, China) Abstract: After oral administration of low, middle, high dose of simulative Maijunan tablets to SD rats and puerarin, hydrochlorothiazide at middle dosage to SD rats separately, plasma samples were collected at different times and treated with acetonitrile to precipitate protein . The contents of puerarin and hydrochlorothiazide in plasma were determined by HPLC method. The mean plasma concentration-time profiles of puerarin and hydrochlorothiazide at different dosages of medication administration were processed by 3P97 pharmacokinetic software and SPSS statistics 17.0 software. The results indicated that the in vivo kinetic processes of puerarin in rats were all fitted to a two-compartment open model and hydrochlorothiazide fitted to a one-compartment open model. Hydrochlorothiazide in vivo kinetic process in rats was in accordance with the linear dynamics. The combination of hydrochlorothiazide and rhynchophylla with pueraria promoted the absorption, reduced the elimination rate and prolonged the action time of puerarin in vivo. Meanwhile,