人参皂苷用于肝脏疾病的研究进展.PDFVIP

·综 述 · 人参皂苷用于肝脏疾病的研究进展  张带荣，冯丹*(华中科技大学同济医学院附属同济医院药学部，武汉 430030) 摘要：人参皂苷是五加科人参属人参的主要有效成分，目前发现其单体多达 150 余种，且不同人参皂苷单体的药理作用 也各有差异。人参皂苷主要有抗肿瘤、抗老年痴呆等作用。近年来的研究表明，人参皂苷在肝脏疾病如肝癌、肝纤维 化、肝损伤和肝炎等，以及肝移植与肝脏切除中已经显现出一定的治疗作用。人参皂苷在肝脏疾病中的作用机制较为复 杂，主要是通过抗氧化、抗炎等作用来保护肝细胞和调节肝功能。本文在查阅国内外文献的基础上，综述了人参皂苷在 肝脏疾病治疗中的研究进展，同时就其作用机制进行了阐述，以期为该成分在肝脏疾病中的进一步研究提供参考。 关键词：人参皂苷；肝脏疾病；药理作用；作用机制 中图分类号：R285 文献标志码：A 文章编号：1007-7693(2016)05-0671-05 DOI: 10.13748/ki.issn1007-7693.2016.05.039 Rsearch Advances on Application of Ginsenosides in Liver Diseases * ZHANG Dairong, FENG Dan (Department of Pharmacy, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China) ABSTRACT: Ginsenoside is the main active ingredient of Ginseng Radix et Rhizoma. More than 150 species of monomers have been found and different monomers have different pharmacological activities. Ginsenosides mainly excert anti-tumor, anti-senile dementia and other pharmacological effects. Recent studies showed that ginsenosides had some therapeutic actions on liver diseases such as hepatocellular carcinoma, hepatic fibrosis, liver damage, and liver regeneration and transplantation. The mechanism of ginsenosides on liver diseases is relatively complicated, mainly through its antioxidant and anti-inflammatory action to protect the liver cells and regulate liver function. This article reviewed the recent researches about treatment of liver diseases with ginsenosides and the mechanisms of ginsenosides, to provide the reference for further research. KEY WORDS: ginsenosides; liver diseases; pharmacological effect; mechanism 人参为五加科人参属的药用植物，作为传统 1 人参皂苷的分类与药理作用 名贵药材，其药用价值极高，具有大补元气、补 迄今为止，已经分离得到的人参皂苷单体多 脾益肺、生津、安神益智等功效。人参皂苷是人 达 1