360份药物不良反应报告研究.doc

360份药物不良反应报告研究【摘要】目的：了解药物不良反应（ADR）的发生和分布情况，为监测提供依据和对临床用药的安全性做出评价，并提出解决办法，提高报告质量。方法：采用回顾性研究方法结合EXCEL电子表格对某医院360份ADR进行统计分析。结果：一般程度的ADR最多，占97.77%；青中年（21~40这年龄段）的ADR发病率高，为39.43%；主要累及的系统-器官为皮肤及其附属器，占35.55%，消化系统次之，为27.22%；给药途径以静脉给药为主，占65.55%；抗微生物药物品种占57.86%，单独用药例数占82.78%；90.28%的ADR均治愈。结论：加强药品不良反应监测工作，提高报告质量，保障公众用药安全，减少ADR的发生。 【关键词】药物不良反应；统计；分析；报告质量 文章编号：1009-5519（2007）15-2241-03 中图分类号：R5 文献标识码：A Analysis of 360 copies of adverse drug reaction report ZENG Fan-tao1，XU Yu-hong1，WEN Qing-jun2 (1.The Fourth People’s Hospital of Shenzhen,Shenzhen 518033,China;2.Guangdong College of Pharmacy,Guangzhou 510006,China) 【Abstract】Objective:To analyse some targets of 360 adverse drug reaction(ADR) reports from a hospital in 2006 and investigate the occurrence and distribution of ADR,so as to provide a reference for preventing and managing the ADR and evaluating the safety of clinical medication,put forward the method to solve the existed problems and improve the quality of report.Methods:The retrospective research conbined with excel table was used to analyse 360 copies of ADR report from a hospital in 2006.Results:The ordinary ADR report was maximum accounting for 97.77%;ADR mostly occurred in young and middle-aged people,its incidence rate was 39.43%;the main involved system and organ were skin and its appendix accounting for 35.55%,and the digestive system took the second place accounting for 27.22%;the main route of administration was injected in vein accounting for 65.55%；the antimicrobial drugs accounted for 67.86% and the patients receiving only kind of medicine accounted for 82.78%;about 90.28% of ADR outcomes were cured.Conclusion:Strengthening ADR monitoring and improving the quality of report are the key steps in ensuring the safety of public medication and decreasing the occurrence of ADR. 【Key words】Adverse drug reaction；Statistics；Analysis；Quality of report 分析某医院2006年药物不良反应报告表，了解不良反应的发生和分布情况，为监测提供依据和对临床用药的安全性做出评价，并对存在的问题提出解决办法的建议，提高报告质量。 1 资料与方