三种方案治疗幽门螺杆菌药物成本-效益研究.doc

三种方案治疗幽门螺杆菌药物成本-效益研究【摘 要】 目的:观察三种方案根除幽门螺杆菌(Helicobacter pylori,HP)药物成本与效果关系。方法:182例患者随机分为三组:A组:雷贝拉唑10mg,克拉霉素0.5,呋喃唑酮0.1,2次/d;B组:奥美拉唑20mg,呋喃唑酮0.1,替硝唑0.4,2次/d;C组:奥美拉唑20mg,克拉霉素0.5,阿膜西林1.0,2次/d;1周后停药。结果:三种方案药品成本分别为148.40元、8.55元、146.95元,有效率分别为92.2%、90.2 %、86.0%。结论:A治疗方案,疗效可靠,价格合理,经济条件较好可以使用;B方案,疗效可靠,价格便宜,农村患者可以推扩;C方案,疗效稍逊一筹,价格昂贵,不宜推扩。 【关键词】 幽门螺旋杆菌 方案 成本 效果分析 Cost - benefit analysis for three schedule for treating helicobacter pylori Wu Ximing,et al 【Abstract】 Objective:To observetherelations of the cost-effectiveness of 3 kinds of pharmacotherapentic schemes of Prazoles for helicobacteria pylori (Hp) infectionMethods:182 patietns were randomly assigned to receive Colloidal rabeprazole +clarithromycin,+ furazolidone (Group A), Colloidal omeprazole + furazolidone + Tinidazole (Group B) or Colloidal omeprazole + clarithromycin + amoxicillin (Group C). The course of treatment was1 week for three groups.Results:The cost of 3 kinds of pharmacotherapentic schemes were 148.4 yuan(Group A),8.55yuan(Group B)and 146.95yuan(Group C). The eradication rates of helicobacter pylori in A, B and C groups were 92.2%, 90.2 % and 86.0% .Conclusion:The pharmacotherapentic schemes of A was effective,and not so expensive, which can be used for the patients who were rich. the pharmacotherapentic schemes of B was cheap while effective in helicobacter pylori eradication. which can be used clinically. In countryside.. the pharmacotherapentic schemes of C was so expensive while poor effective, which can not be used clinically. 【Key words】 Helicobacter Pylori Regimen Cost effectiveness Analysis 幽门螺杆菌(Hp)是胃癌Ⅰ类致癌因子,与慢性胃炎和消化性溃疡的关系密切,根除Hp对预防溃疡复发、减少溃疡病并发症的发生率有临床意义[1]。因此,寻找安全、有效、廉价根除HP方案为临床所需。我采用采用三种方案法根除幽门螺杆菌,观察其药物成本效果关系,现报告如下。 1 资料与方法 1.1 一般资料。本组入选的182 例患者均为2007 年10月～2008 年12 月我院收治的门诊患者,均有不同程度的上腹疼痛、反酸嗳气、上腹烧灼感等症状。符合下列条件:①胃镜检查为糜烂性胃窦炎不合并溃疡;② 经C-14呼气试验证实Hp呈强阳性(DOB25%);③两周内未使用质子泵抑制剂、H?2受体阻滞剂、铋剂或抗生素;④无严重心、肝、肾疾病和恶性肿瘤者;⑤非妊娠或哺乳期妇女;⑥无胃、肠手术史; ⑦对观察的药物非过敏者。所有入选患者随机分成三组:A组64 例,B组61 例,C组57 例。三组患