不同方法治疗婴幼儿社区获得性肺炎临床探究.doc

不同方法治疗婴幼儿社区获得性肺炎临床探究[摘要] 目的 探讨婴幼儿社区获得性肺炎(CAP)不同治疗方法的临床疗效和不良反应。方法 100例社区获得性肺炎随机分为阿奇霉素组(A组)50例和头孢呋辛钠组(B组)50例;采用VITEK-AMS微生物分析仪测定病原菌,并用纸片法(Kirby-Bauer)测定病原菌的体外药物敏感性。结果 A组治疗后痊愈45例(90.0%)明显高于B组39例(78.0%);A组退热时间(3.86±0.95)d低于B组(5.01±1.12)d;A组?音消失时间(3.81±0.74)d低于B组(5.17±1.22)d,差异均有统计学意义(P0.05)。结论 阿奇霉素是治疗婴幼儿CAP的首选药物。 [关键词] 社区获得性肺炎; 婴幼儿; 疗效; 不良反应 [中图分类号] R563.1 [文献标识码] A [文章编号] 1673-9701(2010)09-104-02 Clinical Research of Infants with Community-acquired Pneumonia by Different Treatment Methods GUO Naihuo1 CHU Jianyuan1 LI Xiaozhen1 QI Huayun2 1.Department of Community Rehabilitation,Longgang Central Hospital,Shenzhen 518116,China;2.Operating Room,Longgang Central Hospital,Shenzhen 518116,China [Abstract] ObjectiveTo investigate the infants with community-acquired pneumonia(CAP)of different treatment methods of clinical efficacy and adverse reactions. Methods100 cases of community-acquired pneumonia were randomly divided into azithromycin group(A group) 50 cases and cefuroxime sodium group(B group) 50 cases;using VITEK-AMS microbiological analysis to measure the pathogens,and use disk diffusion method (Kirby-Bauer)Determination of pathogenic bacteria in vitro drug sensitivity. ResultsA group after treatment cured 45 cases(90.0%)was significantly higher than the B group of 39 cases(78.0%)(χ2=3.98,P0.05);The incidence of adverse reactions of nausea、vomiting in group A of 3 cases 6.0%(3/50);B group was 8.0%(4/50)(χ2=2.23,P0.05). ConclusionThe drug of Azithromycin were preferred with treatment in infants and young with CAP. [Key words]Community-acquired pneumonia; Infants and young children; Curative effect;Adverse drug reaction 社区获得性肺炎(Community acquired pneumonia,CAP)是指既往健康儿童在医院外或住院48h内罹患的感染性肺实质性炎症的疾病[1]。其患病率、病死率在我国儿童疾病中居首位,本文分析了我社区婴幼儿社区获得性肺炎(CAP)不同治疗方法的临床疗效和不良反应,现报道如下。 1 资料与方法 1.1 一般资料 收集本社区2003年10月～2007年10月社区获得性肺炎(CAP)患儿100例(男56例,女44例),年龄2.5个月～2.5年,平均年龄为(1.5±0.7)岁;支气管炎35例(35.0%);支气管肺炎65例(65.0%);随机分为阿奇霉素组(A组)50例和头孢呋辛钠组(B组)50例。入选病例严格按照中华呼吸学会199