不同透析膜对尿毒症患者内皮素-1-血清胱抑素C影响.doc

不同透析膜对尿毒症患者内皮素-1\血清胱抑素C影响[摘要] 目的 比较不同透析膜、不同血液净化方式对血透患者血管活性物质的清除。方法 聚砜膜血液透析滤过HDF组用放免法测定透析前后内皮素-1（ET-1）、尿素氮（BUN）、肌酐（SCr）乳胶指标，用增强免疫比浊法测定血清胱抑素C（Cys-c）等指标。双醋酸膜（FB-130）HD组也用放免法测定透析前后ET-1、BUN、SCr乳胶指标，用增强免疫比浊法测定血清Cys-c等指标。1个月后复查透析前ET-1等指标。结果 聚砜膜HDF组单次透析ET-1血透后低于血透前（P＜0.05），而HD组透析前后无明显差异。聚砜膜HDF组1个月后ET-1均较前有所下降（P＜0.01）。结论 HDF可部分清除血透患者血浆中ET-1含量，HDF可减轻炎症反应和组织损伤。维持性血透患者定期进行HDF治疗，能加强治疗效果，提高生存质量。 [关键词] 血液透析滤过；内皮素-1；聚砜膜；血清胱抑素C [中图分类号] R692.5 [文献标识码] B[文章编号] 1673-9701（2011）25-63-02 Effects of Dialysis Membranes on ET-1 and Serum Cystatin C in Uremic Patients FAN Yuliang1LIU Qin1LU Yao1WU Xiuqin1JIN Lei2 1.Department of Nephrology, Huangpu District Central Hospital, Shanghai 200002, China; 2.Science and Technology Development Laboratory of Shanghai Jiaotong University, Shanghai 200002, China [Abstract] Objective To compare the clearance of vasoactive substances of different dialysis membranes and different blood purification for patients on hemodialysis. Methods Polysulfone membrane hemodiafiltration HDF group which measured indicators of radioimmunoassay before and after dialysis, endothelin (ET-1), blood urea nitrogen (BUN), creatinine (Serum) and Latex and measured indicators by enhanced immunoturbidimetric method for measuring serum cystatin C (Cys-c) and other indicators. Review ET-1 and other indicators after one month before dialysis. Diacetate membrane (FB-130) HD group, also measured by radioimmunoassay before and after dialysis, endothelin (ET-1), urea nitrogen (BUN), creatinine (SCr) latex indicators, with the enhanced immunoturbidimetric method for measuring serum cystatin C (Cys-c) and other indicators. ET-1 will be reviewed of pre-dialysis and other indicators after one month. Results HDF group?s ET-1 decreases (P＜0.05) after hemodialysis than before hemodialysis which tested by Polysulfone membrane dialysis single, while the HD group was no significant difference before and after dialysis. Polysulfone membrane HDF groups ET-1 decreased (P＜0.01) than a