吸入舒利迭对慢性阻塞性肺疾病患者血浆炎症细胞因子及肺功能影响.doc

吸入舒利迭对慢性阻塞性肺疾病患者血浆炎症细胞因子及肺功能影响[摘要] 目的 探讨吸入舒利迭对慢性阻塞性肺疾病（COPD）患者血浆炎症细胞因子和肺功能的影响。方法 将70例COPD患者随机分为舒利迭组和对照组。对照组常规予以吸氧、抗感染、止咳化痰及平喘等治疗。舒利迭组在此基础上加用舒利迭（沙美特罗/酸氟替卡松）吸入，连用1周。结果 治疗1周后，两组患者血浆IL-6和IL-8水平均明显下降，血浆IL-10水平明显上升（P＜0.05或P＜0.01），且舒利迭组上升或下降的幅度更明显（P＜0.05）。同时两组患者FEV1、FEV1/FVC和PEF均明显改善（P＜0.05或P＜0.01），且舒利迭组改善的幅度更明显（P＜0.05）。结论 舒利迭吸入治疗COPD的疗效确切，能明显改善患者的肺功能，作用机制与其能调节血浆炎症细胞因子的表达有关。 [关键词] 慢性阻塞性肺疾病；舒利迭；肺功能；炎症细胞因子 [中图分类号] R563 [文献标识码] B [文章编号] 1673-9701（2011）26-60-02 The Effects of Inhaled Fluticasone Propionate on Plasma Inflammatory Cytokines and Pulmonary Function in Patients with Chronic Obstructive Pulmonary Disease CAO Qifeng Department of Pulmonary Medicine，Zeguo Branch of Taizhou Hospital of Integrated Traditional Chinese and Western Medicine，Taizhou 317523，China [Abstract] Objective To investigate the effects of inhaled fluticasone propionate（FP）on plasma inflammatory cytokines and pulmonary function in patients with chronic obstructive pulmonary disease（COPD）. Methods All 70 patients with COPD were divided into two groups randomly，the FP group and the control group. Control group were received the treatment of oxygen，antibiotics，drugs for relieving cough， sputum and asthma， and other symptomatic and supportive treatment. The FP group received an additional treatment of inhaled FP per day for 1 weeks. Results Plasma IL-6 and IL-8 levels decreased significantly and IL-10 levels increased significantly in both two groups after 1 weeks’ therapy（P＜0.05 or P＜0.01）. But the change was more significant in the FP group（P＜0.05）. Both two groups showed significant changes in the pulmonary function（FEV1，FEV1/FVC and PEF）in both two groups after 1 weeks therapy（P＜0.05 or P＜0.01），but the FP group improved more significantly than the control group（P＜0.05）. Conclusion Inhaled FP could improve pulmonary function with COPD，the mechanism may be related to regulating on the expressions of plasma inflammatory cytokines. [Key words] Chronic obstructive pulmonary disease；Flu