干扰素α-2b联合苦参素对慢性乙型肝炎患者T淋巴细胞亚群影响.doc

干扰素α-2b联合苦参素对慢性乙型肝炎患者T淋巴细胞亚群影响[摘要] 目的 研究干扰素α-2b联合苦参素对慢性乙型肝炎的临床疗效及对T淋巴细胞亚群的影响。 方法 将108例慢性乙型肝炎患者随机分为对照组和治疗组，对照组给予干扰素α-2b，治疗组在对照组的基础上给予苦参素，连续给药3个月，评价两组的临床疗效。 结果 治疗组患者HBV DNA转阴率、HBeAg转阴率及HBeAg/抗HBe血清转换率均高于对照组（P ＜ 0.05）；治疗组治疗3个月后CD3+、CD4+细胞数和CD4+/CD8+比值较治疗前显著升高，与对照组比较差异有统计学意义（P ＜ 0.05）。 结论 干扰素α-2b联合苦参素可改善慢性乙型肝炎患者外周血T淋巴细胞亚群状态，具有确切的临床疗效，是一种可靠的治疗方案。 [关键词] 干扰素α-2b；苦参素；慢性乙型肝炎；T淋巴细胞 [中图分类号] R512.6+2 [文献标识码] B [文章编号] 1673-9701（2012）06-0055-02 Effect of IFN α-2b combined with Oxymatrine on T-lymphocyte subsets in patients with chronic hepatitis B FANG Xiang ZHANG Liping XU Tiehua Department of Traditional Chinese Medicine, the People’s Hospital of Lanxi City in Zhejiang Province, Lanxi 321100, China [Abstract] Objective To study the effect of IFN α-2b and Oxymatrine on T-lymphocyte subsets in patients with chronic hepatitis B. Methods All of 108 cases chronic hepatitis B were divided into control group and treatment group. The control group was given IFN α-2b, and the treatment group was given Oxymatrine for 3 months continuously on the basis of control group. The clinical effect was evaluated. Results The negative conversion rates of HBV DNA and HBeAg and HBeAg/anti-HBe serconversion rate were significantly higher in the treatment group than in the control group (P ＜ 0.05). After 3 months, the percentages of CD3+, CD4+ and CD4+/CD8+ T-lymphocytes were significantly higher in the treatment group than in the control group (P ＜ 0.05). Conclusion IFN α-2b and Oxymatrine can improve efficacy and increase the percentages of T-lymphocytes in patients with chronic hepatitis B, and it is a reliable evidence for treatment of chronic hepatitis B. [Key words] IFN α-2b; Oxymatrine; Chronic hepatitis B; T-lymphocyte 现代医学研究发现，机体免疫功能紊乱或低下是导致慢性乙型肝炎的主要原因，因此治疗慢性乙型肝炎以抗病毒及增强机体免疫功能为主[1]。目前国内外公认的抗病毒药物之一是干扰素，具有抗病毒、抗纤维化及免疫调节等多种生物活性，但是干扰素直接抑制病毒复制的能力有限，治疗慢性乙型肝炎的临床疗效较差，寻找安全、有效的联合治疗方法仍是临床医生所关注的问题。我院采用干扰素α-2b联合苦参素治疗慢性乙型肝炎取得较为满意的疗效，现报道如下。 1 资料与方法 1.1 一般资料 选取2009年8月～2010年8月在我院