新生儿缺氧缺血性脑病及血糖临床分析.doc

新生儿缺氧缺血性脑病及血糖临床分析[摘要] 目的 探讨新生儿缺氧缺血性脑病（HIE）与患儿血糖的关系，为临床工作提供参考。方法 观察HIE患儿的血糖水平与其病情严重程度的相关性，以正常新生儿为对照组，比较不同程度HIE患儿血糖水平的平均值以及血糖异常构成比。结果 HIE患儿血糖水平明显高于对照组，差异有统计学意义（P ＜ 0.05）。重度HIE组患儿平均血糖与轻度、中度HIE组患儿比较，差异有统计学意义（P ＜ 0.05）。重度HIE患儿血糖异常发生率明显高于轻度、中度HIE组患儿（P ＜ 0.05）。结论 临床对HIE患儿进行抢救时，须重视观察血糖水平的变化，并根据患儿的血糖值采取不同措施，可有效减少后遗症的发生。 [关键词] 新生儿；缺氧缺血性脑病；血糖分析；血糖监测 [中图分类号] R722.1 [文献标识码] B [文章编号] 1673-9701（2012）03-0061-03 Clinical analysis of hypoxic-ischemic encephalopathy and blood glucose XIANG Caixia Department of Pediatrics, Zhejiang Province Shengzhou City People’s Hospital, Shengzhou 312400, China [Abstract] Objective To investigate the the relationship between the hypoxic ischemic encephalopathy (HIE) and the blood glucose level, to provide reference for clinical work. Methods Observed the blood glucose level and HIE severity correlated, in normal newborns as control group, compared the differences in the degree of children with HIE blood glucose levels and glucose abnormalities than average. Results HIE patients blood glucose level was significantly higher than the control group, and there were statistically significant differences (P ＜ 0.05). Children with severe HIE group mean blood glucose and mild, moderate in HIE group were compared, and there was statistical significance (P ＜ 0.05). Severe HIE with abnormal blood glucose was significantly higher than that in mild, moderate HIE groups (P ＜ 0.05). Conclusion When given the clinical rescue of HIE children, attention should be paid to observe changes in glucose levels, and in accordance with blood glucose values take various kinds of measures, which can effectively reduce the occurrence of sequelae. [Key words] Newborns; Hypoxic-ischemic encephalopathy; Blood glucose analysis; Blood glucose monitoring 新生儿缺氧缺血性脑病，即HIE（hypoxic-ischemic encephalopathy）是临床常见新生儿疾病，多发生于新生儿窒息后[1]。此疾病的发生导致新生儿的脑细胞受损，导致新生儿死亡或影响其神经系统发育障碍[2，3]。新生儿发生缺氧缺血后，会对代谢有着重要影响，表现之一即为糖代谢紊乱，患儿易出现应激性的高血糖或低血糖，而糖代谢紊乱的发生又将进一步加重脑细胞的损害[4]。这种糖代谢紊乱发生在危重患儿中是一