早期应用神经节苷脂治疗急性脑卒中及其对TNF-α及IL-6变化影响.doc

早期应用神经节苷脂治疗急性脑卒中及其对TNF-α及IL-6变化影响[摘要] 目的 通过观察神经节苷脂对急性脑卒中患者的治疗效果及其治疗前后血清中TNF-α和IL-6浓度，探讨神经节苷脂对急性脑卒中患者的治疗作用。方法 将2009年1月～2011年1月入住我院的78例急性脑卒中患者随机分为对照组与观察组，对照组给予脑活素治疗，观察组给予神经节苷脂治疗。观察治疗前后患者的FM评分及其血清中TNF-α及IL-6的浓度变化。结果 两组患者治疗后的FM评分较其治疗前均明显升高（P＜0.05），而观察组患者治疗后的FM评分较对照组治疗后明显升高（P＜0.05）；两组患者治疗后的血清TNF-α、IL-6浓度较其治疗前均明显降低（P＜0.05），而观察组患者治疗后的血清TNF-α、IL-6浓度较对照组治疗后明显降低（P＜0.05）。结论 神经节苷脂对急性脑卒中患者的治疗效果较好，其作用机制可能为通过降低患者血清中的TNF-α及IL-6的浓度，来保护患者脑神经细胞。 [关键词] 神经节苷脂；急性脑卒中；肿瘤坏死因子α；白介素-8 [中图分类号] R743 [文献标识码] B[文章编号] 1673-9701（2011）20-83-02 Using Ganglioside Early to Treat Acute Stroke and The Effect of the Change inTNF-αand IL-6 YE Changjun Department of Neurology，The People’s Hospital of Pingyang in Zhejiang Province，Pingyang 325400，China [Abstract] Objective To discuss the gangliosides mechanism for acute stroke by observing the ganglioside’s treatment effect for acute stroke and their change in TNF-αand IL-6. Methods 78 patients with acute stroke in our hospital during January 2009 to January 2011 were randomly divided into control group and observation group. The control group was given brain anticoagulant treatments and the observation group was given ganglioside treatment. Observed the FM score and the concentration of TNF-αand IL-6 before and after treatment. Results Two groups’ FM score of patients after treatment were significantly higher than that before treatment（P＜0.05），after treatment，the FM score of observation group patients were higher than that of control group（P＜0.05）；Two groups TNF-αand IL-6 of patients after treatment were significantly lower than those before treatment（P＜0.05），and after treatment，the TNF-αand IL-6 of observation group patients were lower than those of control group（P＜0.05）. Conclusion The effect of the ganglioside’ treatment is better，it maybe protect the brain by lowering TNF-αand IL-6. [Key words] Ganglioside；Acute stroke；Tumor necrosis factor α（TNF-α）；Interleukin-6（IL-6） 急性脑卒中是危害人类健康的常见病和多发病，是许多患者导致残障和死亡的主要原因。在我国脑血管疾病中，急性脑卒中致死率为第3位