氢氯噻嗪-苯那普利小剂量联用治疗高血压病52例疗效观察.doc

氢氯噻嗪\苯那普利小剂量联用治疗高血压病52例疗效观察【摘要】目的 观察小剂量氢氯噻嗪、苯那普利联用治疗高血压病的临床疗效。方法 选择52例高血压病患者服用氢氯噻嗪、苯那普利初始剂量每日分别为6.25mg和2.5mg,视降压效果二者最大量每日分别为12.5mg和10mg为目标剂量,疗程12周,观察治疗前后血压、心率及血生化变化。 结果 52例病人全部完成实验,无明显不良反应,血肌酐水平变化不明显。治疗后收缩压、舒张压分别降低(16±3.8)mmHg和(15±4.3)mmHg。与治疗前比较差异有显著性。结论小剂量氢氯噻嗪、苯那普利联合治疗高血压病安全有效。 【关键词】 小剂量 氢氯噻嗪苯那普利 联合用药 高血压病 中图分类号:R916.691文献标识码:A文章编号:1005-0515(2010)08-242-02 【Abstract】ObjectiveObserves the small dosage hydrogen warduzide, benzene that Pulley to unite with treats the clinical curative effect which hypertension gets sick. Methods Chooses 52 example hypertension sickness patient to take the hydrogen warduzide, the benzene that Pulley initial dosage respectively is every day 6.25mg and 2.5mg, Regards voltage dropping effect the two most massive respectively is every day 12.5mg and 10mg is the goal dosage, the treatment course 12 weeks, around the observation treatment the blood pressure, the heart rate and the blood biochemistry change.Results52 example patients complete the experiment completely, not obvious untoward effect, the blood myo- bitter wine level change is not obvious. After the treatment, the systolic pressure, the diastolic pressure reduce (16±3.8) mmHg separately and (15±4.3) mmHg. The comparison difference has the significance before the treatment. Conclusion The small dosage hydrogen warduzide, benzene that Pulley treat hypertension to get sick safely jointly effective. 【Key words】Small dosage Hydrogen warduzide Benzene that Pulley Union medication Hypertension sickness 为取得最大程度高血压治疗效果和最低不良反应,我们用氢氯噻嗪与苯那普利小剂量联用治疗高血压病52例,报道如下: 1 对象与方法 1.1对象选择本院门诊确诊高血压病患者52例为观察对象,其中男32例,女20例。年龄26-72岁,(平均42±8.6岁)。病程两个月-36年(5.8±5.6年)。血压水平:收缩压156±18mmHg,舒张压98±10mmHg。基础疾病构成:2型糖尿病3例,冠心病6例,脑梗塞2例,血脂异常5例。排除对象:对ACEI过敏者,双侧或单侧肾动脉狭窄合并肾功能不全者,妊娠期妇女。 1.2给药方法 用药前已服降压药者全部停服,经5个药物半衰期的洗脱期,服用氢氯噻嗪6.25mg、苯那普利2.5mg,均为每日一次,视血压下降情况,每三周剂量增加一次。目标剂量:氢氯噻嗪12.5mgqd。苯那普利10mg qd,总疗程12周。 1.3观察项目及疗效评价 治疗期间每周测血压两次,重点对比治疗前与疗程结束所测血压、评价降压效果。治疗前后分别做心脏彩超评价心功能,化验血电解质、血尿酸、血肌酐、肝功能,观察记录药物不良反