生脉注射液治疗透析相关性低血压36例疗效观察.docVIP

生脉注射液治疗透析相关性低血压36例疗效观察[摘要] 目的：观察生脉注射液治疗透析相关性低血压的疗效。方法：36例发生透析相关性低血压的维持性血液透析患者随机分为两组，对照组16例给予50%葡萄糖静脉滴注+常规治疗，治疗组给予生脉注射液治疗低血压，并连续观察两组各5次的治疗效果。结果：生脉注射液治疗组低血压发生率低于对照组，差异有统计学意义（P＜0.01）；治疗组治疗有效率高于对照组，差异有统计学意义（P＜0.05）。结论：生脉注射液治疗透析相关性低血压疗效确切，值得临床推广应用。 [关键词] 生脉注射液；血液透析；低血压 [中图分类号] R259 [文献标识码]B [文章编号]1673-7210（2009）03（b）-063－０2 Analysis of Shengmai Injection in the treatment of 36 cases with dialysis-related hypotension YU Hong (Liu Yang Hospital of Traditionrl Chinese Medicine，Hunan Province, Liuyang410300, China) [Abstract] Objective: To observe the effect of Shengmai Injection in the treatment of cases with dialysis-related hypotension. Methods: 36 maintenance hemodialysis patients with dialysis-related hypotension were matched with their own and got two group. At first, cases in normal group were given 50% Glucose injection and conventional treatment to deal with the hypotension. Then cases in control group were given Shengmai Injection. Each group would be continuously observed the effect for five times. Results: The rate of hypotension in control group was lower than that in normal group (P＜0.01). The improvement in symptoms and side effects were also better than the control group（P＜0.05）. Conclusion: The effect of Shengmai Injection in the treatment of dialysis-related hypotension is determined and fewer side effects. [Key words] Shengmai Injection; Hemodialysis; Hypotension 低血压是慢性肾功能衰竭维持性血液透析(血透)患者常见的急性并发症之一，其发生率达20%～40%[1]。血液透析是治疗尿毒症的重要手段，但透析中的低血压常使血透无法顺利进行，严重时直接威胁到患者的生命。低血压的发生是患者提早结束透析的重要原因，并由此降低透析充分性。我们应用生脉注射液治疗36例透析相关性低血压，取得了满意疗效，现报道如下： 1资料与方法 1.1一般资料 选择2005年1月～2008年1月在我院进行维持性血液透析的尿毒症患者138例，其中36例在既往透析过程反复出现低血压，男20例，女16例；平均年龄53.5岁；开始透析的时间为3个月～3.5年；均使用费森尤斯4008 H/S透析机、F6 HPS聚砜膜透析器及碳酸氢盐透析，每周透析2～3次，每次4 h，普通肝素抗凝，透析当日未服用降压药。36例患者随机分为两组，治疗组20例，对照组16例，两组患者性别、年龄、开始透析的时间等一般资料间有均衡性。 1.2方法 36例患者，每例均透析5次。对照组给予50%葡萄糖250 ml快速静滴＋常规方法治疗透析相关性低血压，包括减少或停止超滤、减慢血流量、调高透析液钠浓度等。治疗组在透析开始时给予0.9%氯化钠溶液250 ml＋生脉注射液60 ml静脉滴注。透析过程中每小时测量同侧上肢肱动脉血压一次，由同一护士完成，同