血清IL-6、hs-CRP浓度测定在小儿肺炎支原体肺炎治疗中临床意义.docVIP

血清IL-6、hs-CRP浓度测定在小儿肺炎支原体肺炎治疗中临床意义[摘要] 目的：探讨血清白介素-6（IL-6）、超敏C反应蛋白（hs-CRP）浓度的测定在小儿肺炎支原体肺炎（MPP）治疗中的意义。方法：选择2010年3月～2011年3月我院收治确诊的MPP患儿45例（MPP组），检测MPP患儿治疗前后的血清IL-6、hs-CRP浓度，并选取同期健康体检的儿童30例作为对照组。结果：MPP组治疗前的血清IL-6、hs-CRP的浓度分别是（17.65±2.50）mg/L和（25.32±3.80）mg/L，均高于对照组，差异有高度统计学意义（t=4.47、4.81，P0.05）。结论：肺炎支原体肺炎患儿的血清IL-6和hs-CRP浓度显著升高，提示两者在该病发病机制中有着重要的作用，对肺炎支原体肺炎的早期辅助诊断及指导治疗有重要价值。 [关键词] 儿童；肺炎支原体肺炎；白介素-6；C-反应蛋白 [中图分类号] R725.6 [文献标识码] B [文章编号] 1673-7210（2011）12（b）-097-02 Clinical significance on the determination of serum IL-6, hs-CRP levels in children mycoplasma pneumoniae pneumonia treatment PENG Yan, LIU Zhiwei Clinical Laboratory, Xixiang People’s Hospital of Shenzhen City, Shenzhen 578101, China [Abstract] Objective: To disscuss the significance of serum IL-6, hs-CRP levels determination in children mycoplasma pneumonia (MPP) treatment. Methods: The levels of serum IL-6, hs-CRP were detected before and after treatment in 45 MPP children (MPP group) which were diagnosed from March 2010 to March 2011 in our hospital, and in the same period, 30 healthy children were selected as control group. Results: Children of the MPP groups before treatment of serum IL-6 and hs-CRP levels were (17.65±2.50)mg/L and (25.32±3.80)mg/L respectively, ware higher than the control group, which had significant difference (t=4.47, 4.81, P0.05). Conclusion: The levels of IL-6, hs-CRP increased significantly, it suggests that they have an important role in pathogenesy of MPP and has significant value in the early diagnosis and treatment. [Key words] Children; Mycoplasma pneumonia; Interleukin-6; C-reactive protein 肺炎支原体是肺炎支原体肺炎（MPP）的主要病原体之一，其引发的疾病除了与支原体的直接感染有关外，还与患者本身的免疫功能有关[1]，为进一步探讨支原体肺炎的发病机制及治疗方案，本文对45例MPP患儿在治疗过程中外周血白介素-6（IL-6）和超敏C反应蛋白（hs-CRP）的水平进行检测。为MPP患儿的免疫学诊断和治疗提供理论依据。 1 资料与方法 1.1 一般资料 1.1.1 MPP组 选取2010年3月～2011年3月我院收治确诊的MPP患儿45例，男25例，女20例；年龄1～13岁，平均（5.0±0.8）岁。除发热、咳嗽等症状外，肺部可闻及中小水泡音和（或）X线片检查示肺部病灶，临床诊断符合《实用儿科学》中MPP患儿入选标准[2]，血清抗体肺炎支原体（MP）IgM阳性，且无其他病原感染的临床及实验室证据。患儿采血