阿德福韦酯联合INF-α对慢性乙型肝炎治疗探究.docVIP

阿德福韦酯联合INF-α对慢性乙型肝炎治疗探究摘要: 目的:观察阿德福韦酯联合INF-α对慢性乙型肝炎(CHB)的疗效及对乙型 肝炎病毒脱氧核糖核酸(HBV DNA)的影响。方法:184例CHB患者随机分为治疗组和对照组 ,治疗组92例为阿德福韦酯和INF-α;对照组92例为单用阿德福韦酯,疗程均为12个月, 每 3个月分别检测肝功能#65380;乙型肝炎病毒血清学标志物#65380;HBV DNA。其中40例患者(每组20例 )进行治疗前#65380;后两次肝穿活检。结果:在治疗12个月时,治疗组和对照组的HBV DNA差 异有显著性意义(P0.05).Most of liver histology were improved in 40 patients. Conclusio n: Combined application of INF-α and l Adefovir could enhance the therapeutic eff e ct in treating CHB to certain extent,but effect on HBV DNA should be study furt her more. Key words: chronic hepatitis B;HBV DNA;Adefovir;INF-α 阿德福韦酯在CHB抗病毒治疗上的广泛应用是