胞外pH对中性粒细胞呼吸爆发的影响-中国病理生理杂志.PDF

Ch nese Journal of Pathophys ology 2004, 20( 4) : 683- 685 # 6 83 # [ ] 1000- 4718( 2004) 04 - 06 83- 03 pH * 1, 2 2 , 3 2 1, 2 李艳玲 , 刘承宜 , 段 锐 , 李 燕 1 2 ( , , 510631; 3, 430074) Effects of alterations in extracellular pH on the respiratory burst in neutrophils LI Yan- l ng1, 2, LIU Cheng- y 2, 3 , DUAN Ru 2 , LI Yan1, 2 1 ( The Inf ormation Biology Group of Laboratory of Light Transmission Optics, 2 Laboratory fo Laser Sport Medicine, South China Normal niversity, Guangzhou 510631, China; 3 TheKey Laboratory of Biomedical Photonics fo Ministry of Education fo China and StateKey Laboratory fo Laser Technology, Huazhong niversity of Science and Technology, Wuhan 430074, China) !A Review∀ The resp ratory burst of neutroph ls s an mportant response n nflammat on. The alter at ons n extracellular pH per se s not a suff c ent tr gger to the resp ratory burst n neutroph ls. Wh le neu troph ls n respose to convent onal agon sts , the resp ratory burst n neutroph ls s affected by the alterat ons n - extracellular pH, and there s a d rect relat onsh p between ntracellular and extracellular pH. O # product on 2 - # n neutroph ls s decreased wh le H2O2 product on s ncreased at ac d c pH. O2 release n neutroph ls s en hanced at weak alkal ne pH. Na+ / H+ exc