龙胆苦苷抗炎药理作用研究.PDF

　 　 34 9 2003 9 ·814· Chinese T raditio nal a nd Herbal Drug s ·· 1 2 3 1 1 陈长勋 ,刘占文 ,孙峥嵘 ,宋纯清 ,胡之壁 ( 1. ,　200032; 2. , 　200050; 3. , 　200540) 　: 　。　 , , A、、 ,ig , 。　、、 、 A,。　 , 。 。 : ; ; : 286. 11　　　: 　　　: 0253 2670( 2003) 09 0814 03 R A Studies on anti-inflammatory effect of gentiopicroside 1 2 3 1 1 CHEN Chang-x un , L U Zha n-w en , SUN Zheng -rong , SONG Chun-qing , HU Zhi -bi ( 1. Sha ng hai Univ ersity of TCM , Sha nghai 200032, China; 2. Sha nghai To ng r en Ho spital, Shang hai 200050, China; 3. Sha ng hai Jinshi M edicinal M aterial Co. , Ltd, Shanghai 200540, China) Abstract: Object　To study the anti-inf lamm ato ry eff ect of g entiopicroside ex tract ed f ro m Rad ix Gen - t ianae Marrop hy llae. Methods　The model s of auricular edema in mice induced by dimet hyl benzene, in- creased permeability of celiac blood capillary and body-twi sting reactio n induced by acetic acid, paw sw elling induced by zymo san A, ca rrag eenan and nysta tin in ra ts or in mice w ere prepa red. Then gentiopi- . 　 , croside was giv en to the rat s o r mice by ig Results Gentio picroside inhibit ed the auricular edema de- creased t he permeability of celiac bloo d capillary , reduced the paw swelling induced by carrageenan and zy- , . 　 mo san A but no t by nysta tion Conclusion Gentio picroside ex tracted f rom Rad ix Gent ianae Mar rop hy l - , - . lae ex hibit s obvious a nti inf lammat ory eff ect s : ;