蓝斑内部神经元相关递质及其与ptsd的相关性.doc

蓝斑内部神经元、相关递质及其与PTSD的相关性 侯海佳，陈朗，李文霞，石玉秀* （中国医科大学，辽宁沈阳110001） 【摘要】 蓝斑位于神经中脑核内侧、第四脑室底与侧壁交界处室底灰质的腹外侧区，从面神经核水平一直延伸到中脑下丘平面尾侧，内含蓝斑核，为含黑色素的去甲肾上腺素能神经元聚集的部位。蓝斑核发出的纤维，侧支极为丰富，分布范围广，几乎遍布中枢神经系统各部。现实验研究证明，蓝斑内含多种神经元，如：去甲肾上腺素能神经元、胆碱能神经元、CRH神经元等，通过神经纤维投射到全脑各个部位，影响脑整体活动。创伤后应激障碍是指在遭遇异乎寻常的威胁或灾难后延迟出现并长期持续的精神障碍。相关实验证明，这些神经元分泌递质与 PTSD有一定的相关性。 【关键词】 蓝斑；蓝斑神经元；PTSD Locus ceruleus neurons, neurotransmitter and its correlation with PTSD HOU Hai-jia,CHEN Lang,LI Wen-xia,SHI Yu-xiu (China Medical University, Liaoning Shenyang 110001,China) 【Abstract】 Locus ceruleus neurons in the brain is located in the inner core, at the end of the fourth ventricle and lateral branch at the junction of gray matter at the end of the ventral lateral area, from the nuclear level of the facial nerve in the brain has been extended to the caudal inferior colliculus plane containing the locus ceruleus nucleus, for melanin containing norepinephrine neurons of the parts together. The locus coeruleus fibers distribute in a wide range of ministries in almost all over the central nervous system. Experimental study now shows that includes a variety of locus coeruleus neurons, such as: noradrenergic neurons, cholinergic neurons, CRH neurons and so on, through the nerve fibers projecting to all parts of the whole brain, affecting the overall brain activity. PTSD refers to a threat in the event of unusual or delayed after the disaster and long-term sustainability of the mental disorders. Related experiments show that these neurons secrete neurotransmitters with PTSD have a certain relevance. 【Key words】 Locus ceruleus;locus ceruleus neurons;PTSD 蓝斑（Locus ceruleus, LC）位于神经中脑核内侧、第四脑室底与侧壁交界处室底灰质的腹外侧区，从面神经核水平一直延伸到中脑下丘平面尾侧，内含蓝斑核（nucleus ceruleus），由大量含黑色素的去甲肾上腺素（Norepinephrine，NE）能神经元构成，为前脑中NE激活的神经分布提供了主要的源。蓝斑核发出的神经纤维，侧支极为丰富，分布范围极广，几乎遍布中枢神经系统（Central nervous system, CNS）各部，通过大脑皮质、丘脑、中脑、小脑、脊髓投射，是NE向海马和新皮质输入电流唯一的源，从而影响脑整体活动，如：控制注意力水平；调节觉醒——睡眠周期等。创伤后应激障碍( Posttraumatic stress disorder, PTSD) 是指在遭遇异乎寻常的威胁或灾难后延迟出现并长期持续的精神障碍。其形成与LC密切相关，