米非司酮联合孕三烯酮对子宫内膜异位症患者性激素水平及妊娠结局.doc

米非司酮联合孕三烯酮对子宫内膜异位症患者性激素水平及妊娠结局的影响 童嘉宁(商丘市第一人民医院妇科 河南商丘 476100) [摘要] 目的:探究米非司酮联合孕三烯酮对子宫内膜异位症患者性激素水平及妊娠结局的影响。方法:选取2014年12月至2015年12月商丘市第一人民医院收治的子宫内膜异位症患者50例，随机分成对照组和研究组，各25例。对照组于月经开始第2d采用孕三烯酮口服进行治疗，研究组在对照组治疗基础上加服米非司酮。将两组的治疗效果进行对比。结果:对照组治疗后孕酮（P）、雌二醇 （E2）、黄体生成激素（LH）、卵泡生成激素（FSH）水平高于研究组，妊娠率低于研究组，差异有统计学意义（P＜0.05）；两组患者不良反应率对比差异无统计学意义（P＞0.05）。结论:采用米非司酮与孕三烯酮联合治疗子宫内膜异位症效果明显，安全性良好，可有效调节性激素水平，改善妊娠结局。 [关键词] 子宫内膜异位症；米非司酮；孕三烯酮；性激素水平；妊娠结局 Effect of mifepristone combined with gestrinone on sex hormone and pregnancy outcome in patients with endometriosis Tong Jia-ning (Department of Gynecology, the First Peoples Hospital of Shangqiu, Shangqiu 476100, China) [Abstract] Objective: To investigate the effect of mifepristone combined with gestrinone on sex hormone level and pregnancy outcome in patients with endometriosis. Methods: Fifty patients with endometriosis from December 2014 to December 2015 in Shangqiu First People s Hospital were randomly divided into control group and study group. The control group was treated with gestrinone on the second day after menstruation. The study group received mifepristone on the basis of the control group. The therapeutic effects of the two groups were compared. Results: The levels of progesterone (P), estradiol (E2), luteinizing hormone (LH) and follicle - stimulating hormone (FSH) in the control group were higher than those in the study group, and the difference was statistically significant (P 0.05). There was no significant difference in the adverse reaction rate between the two groups (P 0.05). Conclusion: The combination of mifepristone and gestrinone in the treatment of endometriosis is effective, safe and effective, can effectively regulate the level of sex hormones, improve pregnancy outcome. [Key words] endometriosis; mifepristone; gestrinone; sex hormone level; pregnancy outcome 子宫内膜异位症是指子宫腔内的内膜细胞异位生长引起的妇科疾病[1]。临床发病者因异位内膜周围组织纤维化及周期性出血而出现痛经、月经紊乱，甚至不孕，若治疗不及时病变易累及其他盆腔器官、组织，影响女性身体健康及生育功能[2]。故为探讨更为安全有效的治疗方法，本研究采用米非司酮与孕三烯酮联合治疗子宫内膜异位症。现将结果示下。 1 资