左旋泮托拉唑钠对幽门结扎大鼠胃溃疡模型作用研究-中国试验动物学报.doc

研究报告 左旋泮托拉唑钠对幽门结扎大鼠胃溃疡模型的治疗作用 谭玉娟1，马玉奎2，方超（1. 山东省临朐县人民医院，临朐，山东262600；2. 山东省药学科学院，济南250033） 摘要 目的 研究左旋泮托拉唑钠对幽门结扎大鼠胃溃疡模型。方法 采用幽门结扎大鼠胃溃疡模型，通过检测胃酸分泌量、胃蛋白酶活性、溃疡抑制率、胃泌素水平等指标及胃粘膜组织病理学，全面评价左旋泮托拉唑钠对幽门结扎大鼠胃溃疡模型的作用。结果 左旋泮托拉唑钠 (、、mg/kg, i.v.) 可明显降低模型大鼠胃酸分泌量和血清胃泌素水平，抑制胃蛋白酶活性和溃疡程度，减轻胃粘膜的组织病理学病变。结论 左旋泮托拉唑钠对幽门结扎大鼠胃溃疡模型有明显的改善作用。 关键词 左旋泮托拉唑钠；幽门结扎；胃溃疡；胃蛋白酶【中图分类号】R33【文献标识码】A【文章编号】1671-7856（201）-0000-00 Doi:10.3969/j.issn.1671-7856.2015.008.000 Protective effects of left-handed pantoprazole sodium on rat model of gastric ulcer generated by pyloric ligation TAN Yu-juan1, MA Yu-kui2，Fangeople’s Hospital of Linqu County, Shandong Linqu 262600, China; 2. Shandong Pharmaceutical Academy, Jinan 250033) 【Abstract】 Objective The aim of this study was to investigate the effect of left-handed pantoprazole sodium on rat models of gastric ulcer generated by pyloric ligation. Methods The rat models induced by pylorus ligation were treated with a single intravenous injection of left-handed pantoprazole sodium. The esophagitis suppression rate, volume of gastric juice, activity of pepsin, and level of serum gastrin were determined and gastric mucosa tissue was examined by pathology.?Results The esophagitis index, volume of gastric juice, activity of pepsin and level of serum gastrin in the rats pretreated with left-handed pantoprazole sodium (0.9, 1.8, 3.6 mg/kg, i.v.) were significantly lower than those in the model group. The lesions of gastric mucosa were also improved in the pantoprazole-treated groups. Conclusions Left-handed pantoprazole sodium has remarkable protective effects on the gastric mucosa in rat models of gastric ulcer induced by pyloric ligation. 【Key words】Left-handed pantoprazole sodium; pyloric ligation; gastric ulcer; pepsin; rat [作者简介] （19），，研究方向： 临床药学。[通讯作者] 马玉奎 (1975-)，男，研究方向：评价。 E-mail：yukuima@。为高效的质子泵抑制剂（proton pump inhibitors, PPI），是在奥美拉唑的基础上，对母体结构进行改造后发现的药效更好的药物，H+-K+-ATP酶活性而降低胃酸分泌，从而治疗由于胃酸分泌过多引起的胃和十二指肠溃疡以及反流性食管炎等疾病[1]。泮托拉唑钠为消旋体，其化学结