靶向mirna的肿瘤干细胞治疗策略-tumor.pdf

肿瘤2013 年1 月第33 卷第1 期　TUM OR Vol. 33, J anuary 2013　　 97 DOI: 10.3781/j .issn.1000-7431.2013.01.016 Copyright© 2013 by TUM OR Review 综述 · 靶向miRNA 的肿瘤干细胞治疗策略 1 2 3 陈　勇，徐兴祥 ，陈龙邦 1. 江苏省苏北人民医院肿瘤内科，江苏 扬州　225000 ；2 . 江苏省苏北人民医院呼吸内科，江苏 扬州　225000 ； 3. 南京军区总医院肿瘤内科，江苏南京　2 10002 [摘要]　肿瘤���学说认为，肿瘤组织中存在�小��具有无限增殖、自我更新、放化疗耐受以及高致瘤能力 等���特性的肿瘤��� （cancer stem cells ，CSCs ），它们是肿瘤无法治愈并不断进展的重要原因。微小 RNA （microRNAs ，miRNAs ）是�类短链非编码 RNA ，�过降解 mRNA 或抑制 mRNA 翻译的方式调控着众多基因的 表达。研究显示，miRNA 在多种肿瘤的CSCs 中异常表达，CSCs 的恶性表型维持需要众多miRNA 的参与。近年来， 靶向miRNA 的 CSCs 治疗实验研究已经初步展现出良好的安全性�疗效。针对 miRNA 的治疗策略将成为 CSCs 治疗的�个新的研究方向，最大限度地清除 CSCs 将使治愈肿瘤逐渐成为可能。 [关键词]　肿瘤；肿瘤干细胞；微RNAs [中图分类号]　R730.5 [文献标志码] A [文章编号]　1000-7431 (2013) 01-0097-06 Therapeutic strategies targeting miRNA of cancer stem cells 1 2 3 CHEN Yong , XU Xing-xiang , CHEN Long-bang 1. Department of Medical Oncology, Jiangsu Subei People’s Hospital, Yangzhou 225000, Jiangsu Province, China; 2. Department of Respiratory Medicine, Jiangsu Subei People’s Hospital, Yangzhou 225000, Jiangsu Province, China; 3. Department of Medical Oncology, Nanjing General Hospital of Nanjing Military Command, Nanjing 210002, Jiangsu Province, China [A BSTRACT]　CSCs (cancer stem cells) theory suggests that CSCs are a small subpopulation of cells within tumors that possess characteristics associated with unlimited proliferation, self-renew, radiotherapy and chemotherapy resistance and high tumorigenic ability. Furthermore, CSCs are considered the main source of malignant tumors which become incurable or progress continuously. miRNAs (microRNAs) are a class of short non-coding RNAs that act as master regulators of gene expression through mRNA cleavage or